XB-FEAT-18006528: Difference between revisions

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=dmw=
=''dm-w''=
This is the community wiki page for the gene 'dmw' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.
This is the community wiki page for the gene ''dm-w'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.


=gene function=  
=gene function and orthology=  
The dmw gene is purported to be involved in sex determination in amphibians, and is related to (thus is a paralog of ) the DMRT1 gene family which are sex determining genes in reptiles.
The ''dm-w'' gene is involved in sex determination in amphibians, and is related to (thus is a paralog of) the '''DMRT1''' gene family which are sex determining genes in reptiles.
In X. tropicalis, a diploid ( 2N=20) species, sex determination has been investigated by Monica Bullejos at the Universiidad de Jaen,Spain.
 
She has used cytogenetic analysis to look for sex determining genes at chromosomes at metaphase, but could not see any difference between X. laevis and X. tropicalis.
Hayashi et al 2023, Promoter generation for the chimeric sex-determining gene dm-W in Xenopus frogs, also concur, that there is no ''dm-w in X. tropicalis'':
Chemical induced sex reversal experiments in X. tropicalis determined that the sex determining system is a YW/YZ.   Females are WW or ZW, males are ZZ or ZY or YW.
[[https://www.jstage.jst.go.jp/article/ggs/98/2/98_22-00137/_html/-char/en]]
there are 3 sex chromosomes,  Y W and Z, with the following dominance hierarchy: Y>W>Z. They found that sex chromosomes Y and W have not accumaulated deleterious mutations.
 
They propose that the sex determining gene are on Chromosome 7. (See Wells et al 2011, Development).
[[File:Screenshot 2024-01-31 at 9.06.08 AM.png|thumb]]

Latest revision as of 12:33, 31 January 2024

dm-w

This is the community wiki page for the gene dm-w please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

gene function and orthology

The dm-w gene is involved in sex determination in amphibians, and is related to (thus is a paralog of) the DMRT1 gene family which are sex determining genes in reptiles.

Hayashi et al 2023, Promoter generation for the chimeric sex-determining gene dm-W in Xenopus frogs, also concur, that there is no dm-w in X. tropicalis: [[1]]

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