XB-FEAT-6462420: Difference between revisions
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== | =''btnl2''= | ||
This is the community wiki page for the gene '''' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase | This is the community wiki page for the gene ''btnl2'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase | ||
=nomenclature changes= | =nomenclature changes= | ||
3/9/2015 | 3/9/2015 | ||
Human | |||
Human [Entrez Gene: 56244] and ''Xenopus'' gene names have changed from butyrophilin-like 2 (MHC class II associated) to butyrophilin-like 2 | |||
27JUlY2025 | |||
The ''Xenopus'' gene name has changed from ''butyrophilin-like 2'' to ''butyrophilin like 2'', following the change to the human gene (they removed the hyphen!) | |||
=summary for human BTNL2 from NCBI= | |||
This gene encodes a major histocompatibility complex, class II associated, type I transmembrane protein which belongs to the butyrophilin-like B7 family of immunoregulators. It is thought to be involved in immune surveillance, serving as a negative T-cell regulator by decreasing T-cell proliferation and cytokine release. The encoded protein contains an N-terminal signal peptide, two pairs of immunoglobulin-like domains, separated by a heptad peptide sequence, and a C-terminal transmembrane domain. Naturally occurring mutations in this gene are associated with sarcoidosis, rheumatoid arthritis, ulcerative colitis, inflammatory bowel disease, myositis, type 1 diabetes, systemic lupus erythematosus, acute coronary syndrome, and prostate cancer. [provided by RefSeq, May 2017] | |||
Latest revision as of 19:56, 29 July 2025
btnl2
This is the community wiki page for the gene btnl2 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase
nomenclature changes
3/9/2015
Human [Entrez Gene: 56244] and Xenopus gene names have changed from butyrophilin-like 2 (MHC class II associated) to butyrophilin-like 2
27JUlY2025
The Xenopus gene name has changed from butyrophilin-like 2 to butyrophilin like 2, following the change to the human gene (they removed the hyphen!)
summary for human BTNL2 from NCBI
This gene encodes a major histocompatibility complex, class II associated, type I transmembrane protein which belongs to the butyrophilin-like B7 family of immunoregulators. It is thought to be involved in immune surveillance, serving as a negative T-cell regulator by decreasing T-cell proliferation and cytokine release. The encoded protein contains an N-terminal signal peptide, two pairs of immunoglobulin-like domains, separated by a heptad peptide sequence, and a C-terminal transmembrane domain. Naturally occurring mutations in this gene are associated with sarcoidosis, rheumatoid arthritis, ulcerative colitis, inflammatory bowel disease, myositis, type 1 diabetes, systemic lupus erythematosus, acute coronary syndrome, and prostate cancer. [provided by RefSeq, May 2017]