XB-FEAT-29080258: Difference between revisions
Created page with "=lhb= =nomenclature updates= 16APR2026 ''Xenopus'' gene name changed from ''LOC100490615, lutropin subunit beta-like'' to ''lhb, luteinizing hormone subunit beta''. LOC100490615 (GeneID: 100490615, XP_002939281.1, XB-GENE-29080259) and lhb (GeneID: 100038205, XP_002939280.1, XB-GENE-486113). These two genes are adjacent to each other. human: GYS1< RUVBL2> '''LHB< SAXO3<''' CGB8< CBG2> XTROP: gys1<. ''''lhb'> loc100490615>''' ruvbl2< Xlav.L: gys1.L<. ruvbl2.L>..." |
|||
| (2 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
=lhb= | =''lhb''= | ||
This is the Xenbase wiki page for the ''Xenopus lhb'' genes. Please fee free to record here any relevant information about these genes that is not found elsewhere on Xenbase. | |||
=Summary for human gene from NCBI= | |||
This gene is a member of the glycoprotein hormone beta chain family and encodes the beta subunit of luteinizing hormone (LH). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. LH is expressed in the pituitary gland and promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. The genes for the beta chains of chorionic gonadotropin and for luteinizing hormone are contiguous on chromosome 19q13.3. Mutations in this gene are associated with hypogonadism which is characterized by infertility and pseudohermaphroditism. [provided by RefSeq, Jul 2008] | |||
=nomenclature updates= | =nomenclature updates= | ||
16APR2026 | '''08.23.2019''' | ||
Human name has changed for Entrez Gene: 3972. From ''luteinizing hormone beta polypeptide'' to ''luteinizing hormone subunit beta''. '' | |||
''Xenopus ''genes names updated to match Human name. | |||
'''16APR2026''' | |||
''Xenopus'' gene name changed from ''LOC100490615, lutropin subunit beta-like'' to ''lhb, luteinizing hormone subunit beta''. | ''Xenopus'' gene name changed from ''LOC100490615, lutropin subunit beta-like'' to ''lhb, luteinizing hormone subunit beta''. | ||
Latest revision as of 16:16, 15 April 2026
lhb
This is the Xenbase wiki page for the Xenopus lhb genes. Please fee free to record here any relevant information about these genes that is not found elsewhere on Xenbase.
Summary for human gene from NCBI
This gene is a member of the glycoprotein hormone beta chain family and encodes the beta subunit of luteinizing hormone (LH). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. LH is expressed in the pituitary gland and promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. The genes for the beta chains of chorionic gonadotropin and for luteinizing hormone are contiguous on chromosome 19q13.3. Mutations in this gene are associated with hypogonadism which is characterized by infertility and pseudohermaphroditism. [provided by RefSeq, Jul 2008]
nomenclature updates
08.23.2019
Human name has changed for Entrez Gene: 3972. From luteinizing hormone beta polypeptide to luteinizing hormone subunit beta.
Xenopus genes names updated to match Human name.
16APR2026
Xenopus gene name changed from LOC100490615, lutropin subunit beta-like to lhb, luteinizing hormone subunit beta.
LOC100490615 (GeneID: 100490615, XP_002939281.1, XB-GENE-29080259) and lhb (GeneID: 100038205, XP_002939280.1, XB-GENE-486113). These two genes are adjacent to each other.
human: GYS1< RUVBL2> LHB< SAXO3< CGB8< CBG2>
XTROP: gys1<. 'lhb'> loc100490615> ruvbl2<
Xlav.L: gys1.L<. ruvbl2.L> 'lhb'< lhb.2.L< ntf4.L<
Best alignment of X. tropicalis 137 aa XP_002939281.1 is to 141 aa human LHB protein NP_000885.1. Best alignment of X. tropicalis 332 aa XP_002939280.1 is to 334 aa human SAXO3 protein NP_001382940.1.
Based on protein alignment and synteny, GeneID: 100490615/XB-GENE-29080259 is the ortholog of human LHB and GeneID: 100038205/XB-GENE-486113 is the ortholog of human SAXO3.
Xenopus tropicalis GeneID: 100038205/XB-GENE-486113 is also being changed from lhb to saxo3.
"X. laevis genes Gene D:108696760 [currently hb.2.L ] and GeneID:373843 [currently lhb.L ] need to be assesed.