XB-FEAT-993641: Difference between revisions
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=bcl11b= | =bcl11b= | ||
This is the community wiki page for the gene ''bcl11b'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase | This is the community wiki page for the gene ''bcl11b'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase. | ||
=nomenclature changes= | |||
01/12/2016 | |||
Human name has changed for Entrez Gene: 64919. From B-cell CLL/lymphoma 11B (zinc finger protein) to B-cell CLL/lymphoma 11B. | |||
12/18/2017 | |||
Human name has changed for Entrez Gene: 64919. From B-cell CLL/lymphoma 11B to B cell CLL/lymphoma 11B | |||
=NCBI Summary= | |||
This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. Although the specific function of this gene has not been determined, the encoded protein is known to be a transcriptional repressor, and is regulated by the NURD nucleosome remodeling and histone deacetylase complex. Four alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Aug 2013] | |||
=In situ preparation note= | |||
The community submitted images from the [http://www.xenbase.org/community/lab.do?method=display&labId=352 Patient lab] for this gene show embryos which have been cleared using a 2:1 preparation of benzyl benzoate and benzoic acid (BB:BA or BA:BB). | |||
=Nomenclature updates= | |||
11/06/2018 | |||
Human name has changed for Entrez Gene: 64919. From B cell CLL/lymphoma 11B to BCL11B, BAF complex component | |||
Latest revision as of 13:20, 6 November 2018
bcl11b
This is the community wiki page for the gene bcl11b please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.
nomenclature changes
01/12/2016
Human name has changed for Entrez Gene: 64919. From B-cell CLL/lymphoma 11B (zinc finger protein) to B-cell CLL/lymphoma 11B.
12/18/2017
Human name has changed for Entrez Gene: 64919. From B-cell CLL/lymphoma 11B to B cell CLL/lymphoma 11B
NCBI Summary
This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. Although the specific function of this gene has not been determined, the encoded protein is known to be a transcriptional repressor, and is regulated by the NURD nucleosome remodeling and histone deacetylase complex. Four alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Aug 2013]
In situ preparation note
The community submitted images from the Patient lab for this gene show embryos which have been cleared using a 2:1 preparation of benzyl benzoate and benzoic acid (BB:BA or BA:BB).
Nomenclature updates
11/06/2018 Human name has changed for Entrez Gene: 64919. From B cell CLL/lymphoma 11B to BCL11B, BAF complex component