XB-FEAT-6257607

cxcl8a.1

This is the community wiki page for the gene cxcl8a.1 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

summary from NCBI for human CXCL8: C-X-C motif chemokine ligand 8

The protein encoded by this gene is a member of the CXC chemokine family and is a major mediator of the inflammatory response. The encoded protein is commonly referred to as interleukin-8 (IL-8). IL-8 is secreted by mononuclear macrophages, neutrophils, eosinophils, T lymphocytes, epithelial cells, and fibroblasts. It functions as a chemotactic factor by guiding the neutrophils to the site of infection. Bacterial and viral products rapidly induce IL-8 expression. IL-8 also participates with other cytokines in the proinflammatory signaling cascade and plays a role in systemic inflammatory response syndrome (SIRS). This gene is believed to play a role in the pathogenesis of the lower respiratory tract infection bronchiolitis, a common respiratory tract disease caused by the respiratory syncytial virus (RSV). The overproduction of this proinflammatory protein is thought to cause the lung inflammation associated with csytic fibrosis. This proinflammatory protein is also suspected of playing a role in coronary artery disease and endothelial dysfunction. This protein is also secreted by tumor cells and promotes tumor migration, invasion, angiogenesis and metastasis. This chemokine is also a potent angiogenic factor. The binding of IL-8 to one of its receptors (IL-8RB/CXCR2) increases the permeability of blood vessels and increasing levels of IL-8 are positively correlated with increased severity of multiple disease outcomes (eg, sepsis). This gene and other members of the CXC chemokine gene family form a gene cluster in a region of chromosome 4q. [provided by RefSeq, May 2020]

note on orthologs

no orthologs described for rodents ( mice/rats) or chicken, but cxcl8a is in Zebrafish.

nomenclature changes

09.14.2021 Following review of this gene family by Leon Grayfer and his colleagues&students at George Washington University (with some additional input by Xenbase curators); 2 different clades of “cxcl8” genes/proteins have been described in Xenopus.

See Hauser et al 2021 ( PubMed ID:34489981 for more details)

There are 2 gene groups within each clade, and all genes are orthologs of human CXCL8.

“cxcl8a” genes/proteins both have a ELR (inflammatory chemokine) motif,

“cxcl8b” genes/proteins lack the ELR motif.

The following nomenclature changes have been made.

1) XB-GENEPAGE-6257607 ( Entrez GeneIDs : 100498551 (X.trop); 100036815(Xla.L), 108706769(Xla.S) Gene symbol/gene name updated, changed from cxcl8a chemokine (C-X-C motif) ligand 8a to cxcl8a.1, C-X-C motif chemokine ligand 8a gene 1.

2) XB-GENEPAGE-5945946 ( Entrez GeneIDs: 100498234 (Xtrop) ; 100037000 (Xla.L) (note there is no model for Xla.S)

Gene symbol/ gene name updated, changed from XB5945946 [provisional:cxcl8], provisional ortholog of C-X-C motif chemokine ligand 8 to cxcl8b.2, C-X-C motif chemokine ligand 8b gene 2.

Note that the gene name follows the human syntax.

3) New gene page has been requested for “cxcl8a.2, C-X-C motif chemokine ligand 8a gene 2”

Entrez GeneIDs: 100498389 (Xtrop); 108711090 (Xla.L) ; 108706143 (Xla.S)

Gene models: XBXT10g004080; gene47079, gene19170

Note that the previous names for these LOCs will also be updated:

LOC108711090 alveolar macrophage chemotactic factor Xenopus laevis (L)( gene47079) to cxcl8a.2.L

LOC108706143 alveolar macrophage chemotactic factor Xenopus laevis (S) (gene19170) to cxcl8a.2.S

4) New gene page has been requested for “cxc8b.1, C-X-C motif chemokine ligand 8b gene 1”

Entrez GeneIDs: 101730379 (Xtrop); 108711093* (Xla.L); 108706149**(Xla.S)

Gene models:Xtropv9.1: gene5259; Xtropv10.1 XBXT10g011197; Xla.Lv9.2: gene35942; Xla.S v9.2 gene48128

Note that the previous names for these LOCs will also be updated:

LOC108711093 interleukin-8 (Xla.Lv9.2: gene35942) to cxc8b.1.L

LOC108706149 interleukin-8 (Xla.S gene48128) to cxc8b.1.S