XB-FEAT-978144: Difference between revisions
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Human name has changed for Entrez Gene: 8936. From WAS protein family, member 1 to WAS protein family member 1. | Human name has changed for Entrez Gene: 8936. From WAS protein family, member 1 to WAS protein family member 1. | ||
05.13.19 | |||
Human name has changed for Entrez Gene: 8936. From WAS protein family member 1 to WASP family member 1 | |||
=Summary from NCBI for human WASF1= | |||
The protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein (WASP)-family, plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott-Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] | |||
Latest revision as of 07:58, 15 May 2019
wasf1
This is the community wiki page for the gene wasf1 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.
nomenclature changes
01/12/2016 Human name has changed for Entrez Gene: 8936. From WAS protein family, member 1 to WAS protein family member 1.
05.13.19 Human name has changed for Entrez Gene: 8936. From WAS protein family member 1 to WASP family member 1
Summary from NCBI for human WASF1
The protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein (WASP)-family, plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott-Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]