XB-FEAT-5872748: Difference between revisions
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=selenop2l= | =''selenop2l''= | ||
This is the community wiki page for the gene ''selenop2l'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase. | This is the community wiki page for the gene ''selenop2l'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase. | ||
=nomenclature changes 09/12/2017 | =nomenclature changes= | ||
named changed (XB-GENE-5872749) from selenoprotein P, plasma, 1 to selenoprotein P2-like | 09/12/2017 | ||
symbol changed (XB-GENE-5872749) from unnamed to | |||
named changed (XB-GENE-5872749) from ''selenoprotein P, plasma, 1 to selenoprotein P2-like'' | |||
symbol changed (XB-GENE-5872749) from ''unnamed'' to ''selenop2l'' | |||
=correspondance from NIH= | =correspondance from NIH= | ||
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XB-GENE-5872749) are paralogous genes on chromosome 1 and 4, respectively. | XB-GENE-5872749) are paralogous genes on chromosome 1 and 4, respectively. | ||
selenop encodes a selenoprotein with mutliple selenocysteine (Sec) residues | selenop encodes a selenoprotein with mutliple selenocysteine (Sec) residues (18), similar to SELENOP orthologs in mammals. | ||
(18), similar to SELENOP orthologs in mammals. | |||
'unnamed' has exon structure similar to selenop gene and encodes a protein with high sequence similarity to proteins referred to as selenoprotein Pb or selenoprotein Pb-like | 'unnamed' has exon structure similar to selenop gene and encodes a protein with high sequence similarity to proteins referred to as selenoprotein Pb or selenoprotein Pb-like | ||
(PMIDs:22479358, 11168591), but it is NOT a selenoprotein. | (PMIDs:22479358, 11168591), but it is '''NOT''' a selenoprotein. | ||
Some selenoproteinPb proteins contain a single Sec residue (e.g., zebrafish NP_840083.2 and chicken NP_001335698.1), but in frog, Sec is replaced by cysteine. For this reason, naming this locus is hard because it represents a cysteine-containing | |||
homolog of selenoprotein Pb protein family. | |||
To comply with Gladyshev et al.'s recommendation for naming paralogs (PMID:27645994, in table 3, SELENOP2 is recommended symbol for synonym SELPb), I would like to suggest the following nomenclature update for selenop and 'unnamed', but am open for the naming of the latter: | |||
recommendation for naming paralogs (PMID:27645994, in table 3, SELENOP2 is recommended symbol for synonym SELPb), I would like to suggest the following nomenclature update for selenop and 'unnamed', but am open for the naming of the latter: | |||
current symbol name | current symbol name | ||
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unnamed (XB-GENE-5872749) > selenop2l selenoprotein P2-like | unnamed (XB-GENE-5872749) > selenop2l selenoprotein P2-like | ||
ACTION BY XENBASE: 09/12/17 | |||
Changed | Changed GENE SYMBOLS AND NAMES AS REQUESTED | ||
XB-GENE-5866766 FROM selenop TO selenop1, selenoprotein P1 | |||
XB-GENE-5872749 FROM unnamed TO selenop2l, selenoprotein P2-like | |||
Latest revision as of 08:22, 31 August 2020
selenop2l
This is the community wiki page for the gene selenop2l please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.
nomenclature changes
09/12/2017
named changed (XB-GENE-5872749) from selenoprotein P, plasma, 1 to selenoprotein P2-like
symbol changed (XB-GENE-5872749) from unnamed to selenop2l
correspondance from NIH
from Bhanu Rajput, Ph. D., Staff Scientist, Reference Sequence Project, NCBI/NLM/NIH
3. selenop (GeneID:100379942, XB-GENE-5866766) and 'unnamed' (GeneID:448755,
XB-GENE-5872749) are paralogous genes on chromosome 1 and 4, respectively.
selenop encodes a selenoprotein with mutliple selenocysteine (Sec) residues (18), similar to SELENOP orthologs in mammals.
'unnamed' has exon structure similar to selenop gene and encodes a protein with high sequence similarity to proteins referred to as selenoprotein Pb or selenoprotein Pb-like (PMIDs:22479358, 11168591), but it is NOT a selenoprotein.
Some selenoproteinPb proteins contain a single Sec residue (e.g., zebrafish NP_840083.2 and chicken NP_001335698.1), but in frog, Sec is replaced by cysteine. For this reason, naming this locus is hard because it represents a cysteine-containing homolog of selenoprotein Pb protein family.
To comply with Gladyshev et al.'s recommendation for naming paralogs (PMID:27645994, in table 3, SELENOP2 is recommended symbol for synonym SELPb), I would like to suggest the following nomenclature update for selenop and 'unnamed', but am open for the naming of the latter: current symbol name selenop (XB-GENE-5866766) > selenop1 selenoprotein P1
unnamed (XB-GENE-5872749) > selenop2l selenoprotein P2-like
ACTION BY XENBASE: 09/12/17 Changed GENE SYMBOLS AND NAMES AS REQUESTED
XB-GENE-5866766 FROM selenop TO selenop1, selenoprotein P1
XB-GENE-5872749 FROM unnamed TO selenop2l, selenoprotein P2-like