XB-FEAT-5941915: Difference between revisions
imported>Xenbase gene generator No edit summary |
imported>Xenbase |
||
| (One intermediate revision by one other user not shown) | |||
| Line 1: | Line 1: | ||
=psmd4= | =psmd4= | ||
This is the community wiki page for the gene ''psmd4'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase | This is the community wiki page for the gene ''psmd4'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase | ||
=nomenclature changes= | |||
08/18/2015 | |||
Human name has changed for Entrez Gene: 5710. From proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 to proteasome 26S subunit, non-ATPase 4 | |||
03.17.2021 | |||
Human name has changed for Entrez Gene: 5710. From proteasome 26S subunit, non-ATPase 4 to proteasome 26S subunit ubiquitin receptor, non-ATPase 4 | |||
=summary for human PSMD4 from NCBI= | |||
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. Pseudogenes have been identified on chromosomes 10 and 21. [provided by RefSeq, Jul 2008] | |||
Latest revision as of 10:10, 17 March 2021
psmd4
This is the community wiki page for the gene psmd4 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase
nomenclature changes
08/18/2015
Human name has changed for Entrez Gene: 5710. From proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 to proteasome 26S subunit, non-ATPase 4
03.17.2021
Human name has changed for Entrez Gene: 5710. From proteasome 26S subunit, non-ATPase 4 to proteasome 26S subunit ubiquitin receptor, non-ATPase 4
summary for human PSMD4 from NCBI
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. Pseudogenes have been identified on chromosomes 10 and 21. [provided by RefSeq, Jul 2008]