XB-FEAT-5883771: Difference between revisions
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=hells= | =hells= | ||
This is the community wiki page for the gene ''hells'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase | This is the community wiki page for the gene ''hells'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase | ||
=functrional notes= | |||
from XB-ART-54461, PNAS 2018 January, 115 (5) E876-E885. https://doi.org/10.1073/pnas.1717509115 | |||
HELLS and CDCA7 comprise a bipartite nucleosome remodeling complex defective in ICF syndrome | |||
Christopher Jenness, Simona Giunta, Manuel M. Müller, Hiroshi Kimura, Tom W. Muir and Hironori Funabiki | |||
"HELLS is a SNF2 ATPase family protein, required for de novo DNA methylation of repetitive elements and developmentally programmed genes through interaction with DNMT3b (7). Among six groups of SNF2 family proteins, HELLS belongs to a SNF2-like subfamily, including SMARCA2/4 (BRM/BRG1), CHD3–5 (Mi-2), CHD1/2, CHD6–9, SMARCA1/5 (SNF2L/SNF2h, ISWI) and ALC1 (8). " | |||
=nomenclature changes= | =nomenclature changes= | ||
Latest revision as of 06:21, 9 March 2018
hells
This is the community wiki page for the gene hells please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase
functrional notes
from XB-ART-54461, PNAS 2018 January, 115 (5) E876-E885. https://doi.org/10.1073/pnas.1717509115
HELLS and CDCA7 comprise a bipartite nucleosome remodeling complex defective in ICF syndrome
Christopher Jenness, Simona Giunta, Manuel M. Müller, Hiroshi Kimura, Tom W. Muir and Hironori Funabiki
"HELLS is a SNF2 ATPase family protein, required for de novo DNA methylation of repetitive elements and developmentally programmed genes through interaction with DNMT3b (7). Among six groups of SNF2 family proteins, HELLS belongs to a SNF2-like subfamily, including SMARCA2/4 (BRM/BRG1), CHD3–5 (Mi-2), CHD1/2, CHD6–9, SMARCA1/5 (SNF2L/SNF2h, ISWI) and ALC1 (8). "
nomenclature changes
05/15/2017 Human name has changed for Entrez Gene: 3070. From helicase, lymphoid-specific to helicase, lymphoid specific ( removed hyphen)