XB-FEAT-5717728

ptprt

This is the community wiki page for the gene ptprt please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

nomenclature changes

01/12/2016 Human name has changed for Entrez Gene: 11122. From protein tyrosine phosphatase, receptor type, T to protein tyrosine phosphatase, receptor type T

05.13.19 Human name has changed for Entrez Gene: 11122. From protein tyrosine phosphatase, receptor type T to protein tyrosine phosphatase receptor type T

Summary from NCBI for human PTPRT

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. The protein domain structure and the expression pattern of the mouse counterpart of this PTP suggest its roles in both signal transduction and cellular adhesion in the central nervous system. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]