XB-FEAT-1217426: Difference between revisions
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=st5= | =st5= | ||
This is the community wiki page for the gene ''st5'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase | This is the community wiki page for the gene ''st5'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase | ||
=notes= | |||
The genes called ST5 also has the synonym Dennd2b, as this is a widely used name for this gene in mouse and human work: | |||
NCBI gene page: https://www.ncbi.nlm.nih.gov/gene/6764 | |||
=summary from NCBI= | |||
This gene was identified by its ability to suppress the tumorigenicity of Hela cells in nude mice. The protein encoded by this gene contains a C-terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells. Three alternatively spliced transcript variants of this gene encoding distinct isoforms are identified. [provided by RefSeq, Jul 2008] | |||
Latest revision as of 08:49, 30 August 2017
st5
This is the community wiki page for the gene st5 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase
notes
The genes called ST5 also has the synonym Dennd2b, as this is a widely used name for this gene in mouse and human work:
NCBI gene page: https://www.ncbi.nlm.nih.gov/gene/6764
summary from NCBI
This gene was identified by its ability to suppress the tumorigenicity of Hela cells in nude mice. The protein encoded by this gene contains a C-terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells. Three alternatively spliced transcript variants of this gene encoding distinct isoforms are identified. [provided by RefSeq, Jul 2008]