XB-FEAT-5751696: Difference between revisions
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Human name has changed for Entrez Gene: 2978. guanylate cyclase activator 1A like to guanylate cyclase activator 1A | Human name has changed for Entrez Gene: 2978. guanylate cyclase activator 1A like to guanylate cyclase activator 1A | ||
2018.11.13 | 2018.11.13 | ||
Xenopus gene symbol has changed for genepage ID: 5751696 From guca1a to guca1al | |||
This gene was renamed to guca1a-like, and its gene symbol appended with an "l". | This gene was renamed to guca1a-like, and its gene symbol appended with an "l". | ||
A true syntenic 'guca1a' was discovered, and an accompanying genepage created (XB-GENEPAGE-22061923). | A true syntenic 'guca1a' was discovered, and an accompanying genepage created (XB-GENEPAGE-22061923). | ||
T'''his genepage should be linked to human GUCA1A''' unless further evidence links it to another/different family member. | |||
'''gene symbol and name should NOT be changed back to guca1a per KAB/Xenbase curatorial team.''' | |||
29.11.2022 | |||
further investigation via EggNOG orthology database confirms guca1al protein NP_001072507 as similar to GUCA1A type genes by homology. | |||
Furthermore, top BLASTp:Human search results for guca1al (XB-GENEPAGE-5751696) are GUCA1A protein isoforms, supporting that guca1al is a GUCA1A gene despite no shared synteny with human. | |||
=synteny= | |||
Synteny across human and ''X. tropicalis'' is not conserved, so we can not identify a better human ortholog for this gene, other than GUCA1A | |||
Hsa chr3: FBX040> … HCLS1< …[2x RNApsuedogenes<] … GOLGB1< … IQCB1< …EAF2> | |||
Xtr ch3: golgb1< ...'''guca1al'''> … tcaf2> tcaf1> tcaf#(1.2 or 3) … znf585b< … | |||
Xtr ch2 fbxo40 … | |||
Xtr ch9 : adcy5> … iqcb1< … eaf2> … | |||
=Also known as= | =Also known as= | ||
Latest revision as of 13:13, 30 November 2022
guca1al
This is the community wiki page for the gene guca1al please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.
nomenclature changes
01/12/2016 Human name has changed for Entrez Gene: 2978. From guanylate cyclase activator 1A (retina) to guanylate cyclase activator 1A
07.09.2018
Human name has changed for Entrez Gene: 2978. guanylate cyclase activator 1A like to guanylate cyclase activator 1A
2018.11.13
Xenopus gene symbol has changed for genepage ID: 5751696 From guca1a to guca1al
This gene was renamed to guca1a-like, and its gene symbol appended with an "l".
A true syntenic 'guca1a' was discovered, and an accompanying genepage created (XB-GENEPAGE-22061923).
This genepage should be linked to human GUCA1A unless further evidence links it to another/different family member.
gene symbol and name should NOT be changed back to guca1a per KAB/Xenbase curatorial team.
29.11.2022
further investigation via EggNOG orthology database confirms guca1al protein NP_001072507 as similar to GUCA1A type genes by homology.
Furthermore, top BLASTp:Human search results for guca1al (XB-GENEPAGE-5751696) are GUCA1A protein isoforms, supporting that guca1al is a GUCA1A gene despite no shared synteny with human.
synteny
Synteny across human and X. tropicalis is not conserved, so we can not identify a better human ortholog for this gene, other than GUCA1A
Hsa chr3: FBX040> … HCLS1< …[2x RNApsuedogenes<] … GOLGB1< … IQCB1< …EAF2>
Xtr ch3: golgb1< ...guca1al> … tcaf2> tcaf1> tcaf#(1.2 or 3) … znf585b< …
Xtr ch2 fbxo40 …
Xtr ch9 : adcy5> … iqcb1< … eaf2> …
Also known as
COD3; GCAP; GUCA; GCAP1; GUCA1; CORD14; C6orf131
Summary from NCBI
This gene encodes an enzyme that plays a role in the recovery of retinal photoreceptors from photobleaching. This enzyme promotes the activity of retinal guanylyl cyclase-1 (GC1) at low calcium concentrations and inhibits GC1 at high calcium concentrations. Mutations in this gene can cause cone dystrophy 3 and code-rod dystrophy 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]