XB-FEAT-853932: Difference between revisions
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=ptpn22= | =ptpn22= | ||
This is the community wiki page for the gene ''ptpn22'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase | This is the community wiki page for the gene ''ptpn22'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase | ||
=nomenclature changes= | |||
04/22/ 2016 | |||
Human name has changed for Entrez Gene: 26191. From protein tyrosine phosphatase, non-receptor type 22 (lymphoid) to protein tyrosine phosphatase, non-receptor type 22 | |||
05.13.19 | |||
Human name has changed for Entrez Gene: 26191. From protein tyrosine phosphatase, non-receptor type 22 to protein tyrosine phosphatase non-receptor type 22 | |||
=Summary from NCBI for human PTPN22= | |||
This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Mar 2009] | |||
Latest revision as of 04:54, 15 May 2019
ptpn22
This is the community wiki page for the gene ptpn22 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase
nomenclature changes
04/22/ 2016
Human name has changed for Entrez Gene: 26191. From protein tyrosine phosphatase, non-receptor type 22 (lymphoid) to protein tyrosine phosphatase, non-receptor type 22
05.13.19
Human name has changed for Entrez Gene: 26191. From protein tyrosine phosphatase, non-receptor type 22 to protein tyrosine phosphatase non-receptor type 22
Summary from NCBI for human PTPN22
This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Mar 2009]