XB-FEAT-855662: Difference between revisions
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=il6st= | =il6st= | ||
This is the community wiki page for the gene ''il6st'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase | This is the community wiki page for the gene ''il6st'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase | ||
=nomenclature changes= | |||
10.FEB.2021 | |||
Human name has changed for Entrez Gene: 3572. From interleukin 6 signal transducer to interleukin 6 cytokine family signal transducer | |||
=Summary from NCBVI for human IL6ST= | |||
The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014] | |||
Latest revision as of 14:05, 10 February 2021
il6st
This is the community wiki page for the gene il6st please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase
nomenclature changes
10.FEB.2021
Human name has changed for Entrez Gene: 3572. From interleukin 6 signal transducer to interleukin 6 cytokine family signal transducer
Summary from NCBVI for human IL6ST
The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014]