XB-FEAT-948100: Difference between revisions
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=folr1= | =folr1= | ||
This is the community wiki page for the gene ''folr1'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase | This is the community wiki page for the gene ''folr1'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase. | ||
=nomenclature changes= | |||
Undated | |||
Human name has changed for Entrez Gene: 2348. From folate receptor 1 (adult) to folate receptor 1 | |||
05.13.19 | |||
Human name has changed for Entrez Gene: 2348. From folate receptor 1 to folate receptor alpha | |||
=Summary from NCBI for human FOLR1 = | |||
The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2009] | |||
Latest revision as of 11:26, 21 May 2019
folr1
This is the community wiki page for the gene folr1 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.
nomenclature changes
Undated
Human name has changed for Entrez Gene: 2348. From folate receptor 1 (adult) to folate receptor 1
05.13.19
Human name has changed for Entrez Gene: 2348. From folate receptor 1 to folate receptor alpha
Summary from NCBI for human FOLR1
The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2009]