XB-FEAT-951232: Difference between revisions
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=fmo5= | =fmo5.2= | ||
This is the community wiki page for the gene ''fmo5'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase | This is the community wiki page for the gene ''fmo5.2'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase | ||
Note: there are two FMO5 orthologous genes in Xenopus, predicted to be from a tandem duplication, fmo5.1 and fmo5.2 | |||
=nomenclature changes= | |||
05.13.19 Human name has changed for Entrez Gene: 2330. From flavin containing monooxygenase 5 to flavin containing dimethylaniline monoxygenase 5 | |||
=Summary from NCBI for human FMO5= | |||
Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]renamed to fmo5.2 after discovery of a tandem duplication on 1/3/2019. a new genepage has been requested for fmo5.1 | |||
Latest revision as of 10:28, 15 May 2019
fmo5.2
This is the community wiki page for the gene fmo5.2 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase
Note: there are two FMO5 orthologous genes in Xenopus, predicted to be from a tandem duplication, fmo5.1 and fmo5.2
nomenclature changes
05.13.19 Human name has changed for Entrez Gene: 2330. From flavin containing monooxygenase 5 to flavin containing dimethylaniline monoxygenase 5
Summary from NCBI for human FMO5
Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]renamed to fmo5.2 after discovery of a tandem duplication on 1/3/2019. a new genepage has been requested for fmo5.1