XB-FEAT-955465: Difference between revisions
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=rest= | =rest= | ||
This is the community wiki page for the gene ''rest'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase | This is the community wiki page for the gene ''rest'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase | ||
=nomenclature changes= | |||
04/22/ 2016 | |||
Human name has changed for Entrez Gene: 5978. From RE1-silencing transcription factor to RE1 silencing transcription factor | |||
=Summary for Human gene, from NCBI= | |||
This gene was initially identified as a transcriptional repressor that represses neuronal genes in non-neuronal tissues. However, depending on the cellular context, this gene can act as either an oncogene or a tumor suppressor. The encoded protein is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regulator of neurogenesis. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2018] | |||
Latest revision as of 05:14, 14 May 2019
rest
This is the community wiki page for the gene rest please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase
nomenclature changes
04/22/ 2016
Human name has changed for Entrez Gene: 5978. From RE1-silencing transcription factor to RE1 silencing transcription factor
Summary for Human gene, from NCBI
This gene was initially identified as a transcriptional repressor that represses neuronal genes in non-neuronal tissues. However, depending on the cellular context, this gene can act as either an oncogene or a tumor suppressor. The encoded protein is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regulator of neurogenesis. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2018]