XB-FEAT-984836: Difference between revisions
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=prss12= | =prss12= | ||
This is the community wiki page for the gene ''prss12'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase | This is the community wiki page for the gene ''prss12'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase | ||
= Summary from NCBI= | |||
This gene encodes a member of the trypsin family of serine proteases and contains a signal peptide, a proline-rich region, a Kringle domain, four scavenger receptor cysteine-rich domains, and a trypsin-like serine protease domain. The protein, sometimes referred to as neurotrypsin or motopsin, is secreted from neuronal cells and localizes to the synaptic cleft. Studies in mice show that this protein cleaves a protein, agrin, that is important for the formation and maintenance of exitatory synapses. Defects in this gene cause a form of autosomal recessive cognitive impairment (MRT1). [provided by RefSeq, Jul 2017] | |||
=nomenclature changes= | |||
01/22/2018 | |||
Human name has changed for Entrez Gene: 8492. From protease, serine 12 to serine protease 12 | |||
Latest revision as of 10:04, 23 January 2018
prss12
This is the community wiki page for the gene prss12 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase
Summary from NCBI
This gene encodes a member of the trypsin family of serine proteases and contains a signal peptide, a proline-rich region, a Kringle domain, four scavenger receptor cysteine-rich domains, and a trypsin-like serine protease domain. The protein, sometimes referred to as neurotrypsin or motopsin, is secreted from neuronal cells and localizes to the synaptic cleft. Studies in mice show that this protein cleaves a protein, agrin, that is important for the formation and maintenance of exitatory synapses. Defects in this gene cause a form of autosomal recessive cognitive impairment (MRT1). [provided by RefSeq, Jul 2017]
nomenclature changes
01/22/2018 Human name has changed for Entrez Gene: 8492. From protease, serine 12 to serine protease 12