XB-FEAT-970177: Difference between revisions
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=nomenclature changes= | =nomenclature changes= | ||
08/10/2015 | 08/10/2015 | ||
Human name has changed for Entrez Gene: 7153. From topoisomerase (DNA) II alpha 170kDa to topoisomerase (DNA) II alpha | Human name has changed for Entrez Gene: 7153. From topoisomerase (DNA) II alpha 170kDa to topoisomerase (DNA) II alpha. | ||
08/07/2017 | |||
Human name has changed for Entrez Gene: 7153. From topoisomerase (DNA) II alpha to DNA topoisomerase II alpha | |||
=summary from NCBI= | |||
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010] | |||
Latest revision as of 07:53, 8 August 2017
top2a
This is the community wiki page for the gene top2a please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase
nomenclature changes
08/10/2015 Human name has changed for Entrez Gene: 7153. From topoisomerase (DNA) II alpha 170kDa to topoisomerase (DNA) II alpha.
08/07/2017 Human name has changed for Entrez Gene: 7153. From topoisomerase (DNA) II alpha to DNA topoisomerase II alpha
summary from NCBI
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010]