Chymostatin: Difference between revisions
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imported>Kevin Created page with "==Description== "Chymostatin is a bioactive peptide protease inhibitor that contains chymostatin A as a major form. The compound specifically inhibits chymotrypsin (CTR) (ID50..." |
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"Chymostatin is a bioactive peptide protease inhibitor that contains chymostatin A as a major form. The compound specifically inhibits chymotrypsin (CTR) (ID50 = 150 ηg/ml), papain (ID50 = 7.5 μg/ml), and cathepsin G along with most cysteine proteases such as cathepsin A, B, H, and L. The compound has been noted as a strong inhibitor of cathepsins A, B, and C. Chymostatin at an effective concentration of 10 to 100 μM weakly inhibits human leukocyte Elastase-1. In rat muscle homogenates chymostatin inhibited the protease cathepsin B and other soluble Ca2+ activated proteases. In the same study, chymostatin decreased protein break down by 20-40% without inhibiting protein production." | "Chymostatin is a bioactive peptide protease inhibitor that contains chymostatin A as a major form. The compound specifically inhibits chymotrypsin (CTR) (ID50 = 150 ηg/ml), papain (ID50 = 7.5 μg/ml), and cathepsin G along with most cysteine proteases such as cathepsin A, B, H, and L. The compound has been noted as a strong inhibitor of cathepsins A, B, and C. Chymostatin at an effective concentration of 10 to 100 μM weakly inhibits human leukocyte Elastase-1. In rat muscle homogenates chymostatin inhibited the protease cathepsin B and other soluble Ca2+ activated proteases. In the same study, chymostatin decreased protein break down by 20-40% without inhibiting protein production." | ||
**-Santa Cruz product description | **-Santa Cruz product description | ||
Synonym: N-(Nα-Carbonyl-Cpd-X-Phe-al)-Phe (Cpd = capreomycidine) (capreomycidine = [S,S]-α-(2-Iminohexahydro-4-pyrimidyl)glycine) | Synonym: N-(Nα-Carbonyl-Cpd-X-Phe-al)-Phe (Cpd = capreomycidine) (capreomycidine = [S,S]-α-(2-Iminohexahydro-4-pyrimidyl)glycine) | ||
[[File:chymostatin.png|frame|right|Chymostatin structure, photo from Sigma-Aldrich]] | |||
==Suppliers== | ==Suppliers== | ||
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*[http://www.emdmillipore.com/US/en/product/,EMD_BIO-230790?cid=BI-XX-BRC-P-GOOG-INHI-B319-1843 EMD Millipore] | *[http://www.emdmillipore.com/US/en/product/,EMD_BIO-230790?cid=BI-XX-BRC-P-GOOG-INHI-B319-1843 EMD Millipore] | ||
*[http://www.sigmaaldrich.com/catalog/product/sigma/c7268?lang=en®ion=US&gclid=CjwKEAjw-ZqrBRDt_KjhjcbzhhISJAAlRGvlz7FHeu3zYRwTviYLLFnKY-PDaO2c6xNTFo7AIWOv3xoC4kvw_wcB Sigma] | *[http://www.sigmaaldrich.com/catalog/product/sigma/c7268?lang=en®ion=US&gclid=CjwKEAjw-ZqrBRDt_KjhjcbzhhISJAAlRGvlz7FHeu3zYRwTviYLLFnKY-PDaO2c6xNTFo7AIWOv3xoC4kvw_wcB Sigma] | ||
**Genes Affected | |||
**[http://www.xenbase.org/gene/showgene.do?method=display&geneId=5953470 stsg] | |||
==Usage Notes== | ==Usage Notes== | ||
==References== | ==References== | ||
*[https://pubchem.ncbi.nlm.nih.gov/compound/443119 PubChem] | |||
*[http://www.xenbase.org/literature/article.do?method=display&articleId=16255 Tian et al., 1997] | *[http://www.xenbase.org/literature/article.do?method=display&articleId=16255 Tian et al., 1997] | ||
>464 Xenbase articles contain a reference to chymostatin according to [http://www.xenbase.org/cgi-bin/textpresso/xenopus/search textpresso] | >464 Xenbase articles contain a reference to chymostatin according to [http://www.xenbase.org/cgi-bin/textpresso/xenopus/search textpresso] | ||
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*[[Small Molecules for Xenopus Research|Back To Small Molecules Home Page]] | |||
Latest revision as of 12:36, 2 June 2015
Description
"Chymostatin is a bioactive peptide protease inhibitor that contains chymostatin A as a major form. The compound specifically inhibits chymotrypsin (CTR) (ID50 = 150 ηg/ml), papain (ID50 = 7.5 μg/ml), and cathepsin G along with most cysteine proteases such as cathepsin A, B, H, and L. The compound has been noted as a strong inhibitor of cathepsins A, B, and C. Chymostatin at an effective concentration of 10 to 100 μM weakly inhibits human leukocyte Elastase-1. In rat muscle homogenates chymostatin inhibited the protease cathepsin B and other soluble Ca2+ activated proteases. In the same study, chymostatin decreased protein break down by 20-40% without inhibiting protein production."
- -Santa Cruz product description
Synonym: N-(Nα-Carbonyl-Cpd-X-Phe-al)-Phe (Cpd = capreomycidine) (capreomycidine = [S,S]-α-(2-Iminohexahydro-4-pyrimidyl)glycine)
Suppliers
- Cayman
- Santa Cruz
- EMD Millipore
- Sigma
- Genes Affected
- stsg
Usage Notes
References
>464 Xenbase articles contain a reference to chymostatin according to textpresso