IBMX: Difference between revisions
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imported>Kevin Created page with "==Description== Phosphodiesterase inhibitor. "Biochem/physiol Actions Non-specific inhibitor of cAMP and cGMP phosphodiesterases. The increase in cAMP level as a result of p..." |
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Phosphodiesterase inhibitor. | Phosphodiesterase inhibitor. | ||
"Biochem/physiol Actions | "Biochem/physiol Actions: Non-specific inhibitor of cAMP and cGMP phosphodiesterases. The increase in cAMP level as a result of phosphodiesterase inhibition by IBMX activates PKA leading to decreased proliferation, increased differentiation, and induction of apoptosis. IBMX inhibits phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50: 1.3 μM). Also serves as an adenosine receptor antagonist. Shown to inhibit ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. Induces calcium release from intracellular stores in sensory neurons." | ||
Non-specific inhibitor of cAMP and cGMP phosphodiesterases. The increase in cAMP level as a result of phosphodiesterase inhibition by IBMX activates PKA leading to decreased proliferation, increased differentiation, and induction of apoptosis. IBMX inhibits phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50: 1.3 μM). Also serves as an adenosine receptor antagonist. Shown to inhibit ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. Induces calcium release from intracellular stores in sensory neurons." | |||
*-Sigma Product Description | *-Sigma Product Description | ||
[[File:IBMX.png|frame|right|IBMX structure, photo from Sigma-Aldrich]] | [[File:IBMX.png|frame|right|IBMX structure, photo from Sigma-Aldrich]] | ||
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==References== | ==References== | ||
*[https://pubchem.ncbi.nlm.nih.gov/compound/3758 PubChem] | |||
*[http://www.xenbase.org/literature/article.do?method=display&articleId=11986 Kim et al., 1999] | *[http://www.xenbase.org/literature/article.do?method=display&articleId=11986 Kim et al., 1999] | ||
Latest revision as of 12:48, 2 June 2015
Description
Phosphodiesterase inhibitor.
"Biochem/physiol Actions: Non-specific inhibitor of cAMP and cGMP phosphodiesterases. The increase in cAMP level as a result of phosphodiesterase inhibition by IBMX activates PKA leading to decreased proliferation, increased differentiation, and induction of apoptosis. IBMX inhibits phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50: 1.3 μM). Also serves as an adenosine receptor antagonist. Shown to inhibit ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. Induces calcium release from intracellular stores in sensory neurons."
- -Sigma Product Description
Genes Affected
Suppliers
- Tocris 2845
- Cayman 13347
- Santa Cruz sc-201188
- Enzo
- Life Technologies PHZ1124
- Abcam ab120840
- Sigma-Aldrich i5879
Usage Notes
1mM
References
>452 Xenbase articles contain a reference to IMBX according to textpresso