Suramin: Difference between revisions
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imported>Kevin Created page with "==Description== [[File:______|frame|right|_______ structure, photo from Sigma-Aldrich]] ==Genes Affected== ==Suppliers== *[http://www.xenbase.org/entry/ SORRYONLYALINKTOXENB..." |
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==Description== | ==Description== | ||
[[File: | synonyms: Germanin; Naganol; Naphuride; Belganyl; Suramine | ||
"Suramin is a polysulfonated naphthylurea anticancer agent that inhibits tumor cell proliferation. It inhibits the activity of topoisomerase II by blocking the binding of the enzyme to DNA. It′s antiangiogenic activity may be related to its ability to bind to and inhibit the activity of several growth factors, including FGFa, FGFb, and PGDF. It uncouples G-proteins from receptors. It is an broad spectrum antagonist at P2X and P2Y purinergic receptors. Suramin has well documented antiprotozoal and anthelmintic activity." | |||
*-Sigma product description | |||
[[File:suramin.png|frame|right|suramin structure, photo from pubchem]] | |||
==Genes Affected== | ==Genes Affected== | ||
Topoisomerase II | |||
==Suppliers== | ==Suppliers== | ||
*[http://www. | *Bayer AG | ||
*[http://www.sigmaaldrich.com/catalog/product/sigma/s2671?lang=en®ion=US Sigma] | |||
==Usage Notes== | ==Usage Notes== | ||
150mM in culture | |||
==References== | ==References== | ||
*[https:// | *[https://www.ncbi.nlm.nih.gov/pccompound?term=suramin Pubchem] | ||
*[http://www.xenbase.org/literature/article.do?method=display&articleId= | *[http://www.xenbase.org/literature/article.do?method=display&articleId=12409] | ||
*[http://www.xenbase.org/literature/article.do?method=display&articleId=16506] | |||
> | >209 Xenbase articles contain a reference to suramin according to [http://www.xenbase.org/cgi-bin/textpresso/xenopus/search textpresso] | ||
* | * | ||
*[[Small Molecules for Xenopus Research|Back To Small Molecules Home Page]] | *[[Small Molecules for Xenopus Research|Back To Small Molecules Home Page]] | ||
Latest revision as of 12:44, 2 July 2015
Description
synonyms: Germanin; Naganol; Naphuride; Belganyl; Suramine
"Suramin is a polysulfonated naphthylurea anticancer agent that inhibits tumor cell proliferation. It inhibits the activity of topoisomerase II by blocking the binding of the enzyme to DNA. It′s antiangiogenic activity may be related to its ability to bind to and inhibit the activity of several growth factors, including FGFa, FGFb, and PGDF. It uncouples G-proteins from receptors. It is an broad spectrum antagonist at P2X and P2Y purinergic receptors. Suramin has well documented antiprotozoal and anthelmintic activity."
- -Sigma product description
Genes Affected
Topoisomerase II
Suppliers
- Bayer AG
- Sigma
Usage Notes
150mM in culture
References
>209 Xenbase articles contain a reference to suramin according to textpresso