Y27632: Difference between revisions
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imported>Kevin Created page with "==Description== [[File:______|frame|right|_______ structure, photo from Sigma-Aldrich]] ==Genes Affected== ==Suppliers== *[http://www.xenbase.org/entry/ SORRYONLYALINKTOXENB..." |
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==Description== | ==Description== | ||
[[File: | "Y-27632 is highly potent, cell-permeable, selective ROCK (Rho-associated coiled coil forming protein serine/threonine kinase) inhibitor. Ki = 140 nM for p160ROCK. Y-27632 also inhibits ROCK-II with equal potency. The inhibition is competitive with respect to ATP." | ||
*-Sigma Product Description | |||
[[File:Y27632.png|frame|right|Y27632 structure, photo from Sigma-Aldrich]] | |||
==Genes Affected== | ==Genes Affected== | ||
*[http://www.xenbase.org/gene/showgene.do?method=display&geneId=984660 rock1] | |||
*[http://www.xenbase.org/gene/showgene.do?method=display&geneId=959450 rock2] | |||
==Suppliers== | ==Suppliers== | ||
*[http://www. | *[http://www.sigmaaldrich.com/catalog/product/sigma/y0503?lang=en®ion=US Sigma] | ||
*[http://www.tocris.com/dispprod.php?ItemId=1382#.VZWg2RtVhBc Tocris] | |||
==Usage Notes== | ==Usage Notes== | ||
10uM in culture | |||
==References== | ==References== | ||
*[https://pubchem.ncbi.nlm.nih.gov/ Pubchem] | *[https://pubchem.ncbi.nlm.nih.gov/compound/448042 Pubchem] | ||
*[http://www.xenbase.org/literature/article.do?method=display&articleId= | *[http://www.xenbase.org/literature/article.do?method=display&articleId=44762 Langdon et al., 2012] | ||
*[http://www.xenbase.org/literature/article.do?method=display&articleId=41781 Zhou] | |||
*[http://www.xenbase.org/literature/article.do?method=display&articleId=49645 Kim] | |||
> | >28 Xenbase articles contain a reference to Y27632 or Y-27632 according to [http://www.xenbase.org/cgi-bin/textpresso/xenopus/search textpresso] | ||
* | * | ||
*[[Small Molecules for Xenopus Research|Back To Small Molecules Home Page]] | *[[Small Molecules for Xenopus Research|Back To Small Molecules Home Page]] | ||
Latest revision as of 06:46, 23 March 2016
Description
"Y-27632 is highly potent, cell-permeable, selective ROCK (Rho-associated coiled coil forming protein serine/threonine kinase) inhibitor. Ki = 140 nM for p160ROCK. Y-27632 also inhibits ROCK-II with equal potency. The inhibition is competitive with respect to ATP."
- -Sigma Product Description
Genes Affected
Suppliers
Usage Notes
10uM in culture
References
>28 Xenbase articles contain a reference to Y27632 or Y-27632 according to textpresso