ZM 447439: Difference between revisions
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imported>Kevin Created page with "==Description== [[File:______|frame|right|_______ structure, photo from Sigma-Aldrich]] ==Genes Affected== ==Suppliers== *[http://www.xenbase.org/entry/ SORRYONLYALINKTOXENB..." |
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==Description== | ==Description== | ||
[[File: | "Novel, selective ATP-competitive inhibitor of Aurora B kinase in vitro (IC50 values are 50, 250 and 1000 nM for Aurora B, C and A kinases respectively). Selective over a range of other kinases including cdk1 and PLK1 (IC50 > 10 μM). Inhibits cell division and displays selective toxicity towards proliferating tumor cells versus non-dividing cells." | ||
*-Tocris product description | |||
[[File:ZM447439.png|frame|right|ZM 447439 structure, photo from Pubchem]] | |||
==Genes Affected== | ==Genes Affected== | ||
*[http://www.xenbase.org/gene/showgene.do?method=display&geneId=1019625 aurkb] | |||
==Suppliers== | ==Suppliers== | ||
*[http://www. | *EMD Millipore | ||
*[http://www.tocris.com/dispprod.php?ItemId=154252#.VZWlfhtVhBc Tocris] | |||
*[http://www.selleckchem.com/products/ZM-447439.html Selleck] | |||
*[http://www.scbt.com/datasheet-200696-zm-447439.html Santa Cruz] | |||
*[https://www.caymanchem.com/app/template/Product.vm/catalog/13601 Cayman] | |||
*[http://www.enzolifesciences.com/BML-EI373/zm-447439/ Enzo] | |||
==Usage Notes== | ==Usage Notes== | ||
20uM | |||
==References== | ==References== | ||
*[https://pubchem.ncbi.nlm.nih.gov/ Pubchem] | *[https://pubchem.ncbi.nlm.nih.gov/compound/9914412 Pubchem] | ||
*[http://www.xenbase.org/literature/article.do?method=display&articleId= | *[http://www.xenbase.org/literature/article.do?method=display&articleId=49376 Edens et al., 2014] | ||
*[http://www.xenbase.org/literature/article.do?method=display&articleId=46738] | |||
> | >1 Xenbase articles contain a reference to ZM 447439 according to [http://www.xenbase.org/cgi-bin/textpresso/xenopus/search textpresso] | ||
* | * | ||
*[[Small Molecules for Xenopus Research|Back To Small Molecules Home Page]] | *[[Small Molecules for Xenopus Research|Back To Small Molecules Home Page]] | ||
Latest revision as of 14:07, 2 July 2015
Description
"Novel, selective ATP-competitive inhibitor of Aurora B kinase in vitro (IC50 values are 50, 250 and 1000 nM for Aurora B, C and A kinases respectively). Selective over a range of other kinases including cdk1 and PLK1 (IC50 > 10 μM). Inhibits cell division and displays selective toxicity towards proliferating tumor cells versus non-dividing cells."
- -Tocris product description
Genes Affected
Suppliers
- EMD Millipore
- Tocris
- Selleck
- Santa Cruz
- Cayman
- Enzo
Usage Notes
20uM
References
>1 Xenbase articles contain a reference to ZM 447439 according to textpresso