SB431542: Difference between revisions
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==Description== | ==Description== | ||
"Potent and selective inhibitor of the transforming growth factor-β (TGF-β) type I receptor activin receptor-like kinase ALK5 (IC50 = 94 nM), and its relatives ALK4 and ALK7. Suppresses TGF-β-induced proliferation of human osteosarcoma cells. Stimulates proliferation, differentiation and sheet formation of ESC-derived endothelial cells." | |||
*-Tocris Product Description | |||
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[[File:SB431542.png|frame|right|SB-431542 structure, photo from Sigma-Aldrich]] | |||
==Genes Affected== | ==Genes Affected== | ||
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*[http://www.selleckchem.com/products/SB-431542.html Selleckchem] | *[http://www.selleckchem.com/products/SB-431542.html Selleckchem] | ||
== | ==Usage Notes== | ||
==References== | |||
*[http://www.xenbase.org/literature/article.do?method=display&articleId=371 Ho et al., 2006] | *[http://www.xenbase.org/literature/article.do?method=display&articleId=371 Ho et al., 2006] | ||
* > | *[http://www.xenbase.org/literature/article.do?method=display&articleId=49634 Chiu 2014] | ||
*[http://www.xenbase.org/literature/article.do?method=display&articleId=54570 Sato et al 2018] | |||
*[https://pubchem.ncbi.nlm.nih.gov/compound/4521392 NCBI PubChem CID:4521392] | |||
> 40 Xenbase articles contain a reference to SB431542 according to [http://www.xenbase.org/cgi-bin/textpresso/xenopus/search textpresso] | |||
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*[[Small Molecules for Xenopus Research|Back To Small Molecules Home Page]] | |||
Latest revision as of 12:19, 9 April 2018
Description
"Potent and selective inhibitor of the transforming growth factor-β (TGF-β) type I receptor activin receptor-like kinase ALK5 (IC50 = 94 nM), and its relatives ALK4 and ALK7. Suppresses TGF-β-induced proliferation of human osteosarcoma cells. Stimulates proliferation, differentiation and sheet formation of ESC-derived endothelial cells."
- -Tocris Product Description
Genes Affected
Suppliers
Usage Notes
References
> 40 Xenbase articles contain a reference to SB431542 according to textpresso