Cyclosporin A: Difference between revisions
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imported>Kevin Created page with "http://www.xenbase.org/literature/article.do?method=display&articleId=11687 calbiochem Synonym CsA" |
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==Description== | |||
"Cyclic oligopeptide with immunosuppressant properties. Induces apoptosis in rat thymocytes and in the murine B cell lymphoma cell line, WEH1-231. However, prevents anti-IgM and ionomycin-induced apoptosis in BLB cell lines. The complex of cyclosporin A with cyclophilin inhibits protein phosphatase 2B with nanomolar affinity. Inhibits nitric oxide synthesis induced by interleukin-1α, lipopolysaccharides, and TNF-α. Induces cardiomyocytes from embryonic stem cells." | |||
*-Calbiochem Product Description | |||
==Synonym== | |||
CsA | |||
[[File:cyclosporinA.png|frame|right|Cyclosporin A structure, photo from Pubchem]] | |||
==Genes Affected== | |||
*[http://www.xenbase.org/gene/showgene.do?method=display&geneId=952298 ppp3ca (Calcineurin)] | |||
==Suppliers== | |||
*[http://www.emdmillipore.com/US/en/product/Cyclosporin-A%2C-Tolypocladium-inflatum---CAS-59865-13-3---Calbiochem,EMD_BIO-239835?RedirectedFrom=http://www.emdmillipore.com/products/EMD_BIO-239835 Calbiochem] | |||
==Usage Notes== | |||
==References== | |||
*[https://pubchem.ncbi.nlm.nih.gov/compound/5284373 Pubchem] | |||
*[http://www.xenbase.org/literature/article.do?method=display&articleId=11687 Lautermilch et al., 2000] | |||
>161 Xenbase articles contain a reference to Cyclosporin A according to [http://www.xenbase.org/cgi-bin/textpresso/xenopus/search textpresso] | |||
*[[Small Molecules for Xenopus Research|Back To Small Molecules Home Page]] | |||
Latest revision as of 06:16, 17 September 2018
Description
"Cyclic oligopeptide with immunosuppressant properties. Induces apoptosis in rat thymocytes and in the murine B cell lymphoma cell line, WEH1-231. However, prevents anti-IgM and ionomycin-induced apoptosis in BLB cell lines. The complex of cyclosporin A with cyclophilin inhibits protein phosphatase 2B with nanomolar affinity. Inhibits nitric oxide synthesis induced by interleukin-1α, lipopolysaccharides, and TNF-α. Induces cardiomyocytes from embryonic stem cells."
- -Calbiochem Product Description
Synonym
CsA
Genes Affected
Suppliers
Usage Notes
References
>161 Xenbase articles contain a reference to Cyclosporin A according to textpresso