BMS-453: Difference between revisions

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==Description==
==Description==
Synthetic retinoid. Retinoic acid receptor β (RARβ) agonist in vivo; RARα and RARγ antagonist in vitro. Inhibits breast cell proliferation by inducing active transforming growth factor β (TGFβ) and causes G1 arrest.
Synthetic retinoid. Retinoic acid receptor β (RARβ) agonist in vivo; RARα and RARγ antagonist in vitro. Inhibits breast cell proliferation by inducing active transforming growth factor β (TGFβ) and causes G1 arrest.
[[File:bms 453.structure.png|frame|right|Bms 453 structure, photo from Tocris]]  
[[File:bms 453.structure.png|frame|right|Bms 453 structure, image from NCBI Pubchem]]  
==Alternative Name==  
==Alternative Name==  
BMS 189453
BMS 189453
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4-[(1E)-2-(5,6-Dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl)ethenyl]-benzoic acid
4-[(1E)-2-(5,6-Dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl)ethenyl]-benzoic acid
==Suppliers==
==Suppliers==
*[https://www.tocris.com/dispprod.php?ItemId=222005#.V2xIRfkrKM8 Tocris]
[https://www.tocris.com/dispprod.php?ItemId=222005#.V2xIRfkrKM8 Tocris]
==References==
==References==
*[http://www.xenbase.org/literature/article.do?method=display&articleId=51800| ''Using frogs faces to dissect the mechanisms underlying human orofacial defects''. Dickinson AJ. Semin Cell Dev Biol. March 1, 2016; 51 54-63.]
*[http://www.xenbase.org/literature/article.do?method=display&articleId=51800| ''Using frogs faces to dissect the mechanisms underlying human orofacial defects''. Dickinson AJ. Semin Cell Dev Biol. March 1, 2016; 51 54-63.]
*[http://www.xenbase.org/literature/article.do?articleId=44961&method=display| ''Median facial clefts in Xenopus laevis: roles of retinoic acid signaling and homeobox genes.'' Kennedy AE, Dickinson AJ. Dev Biol. May 1, 2012; 365 (1): 229-40.]
*National Center for Biotechnology Information. PubChem Compound Database; CID=9875424, [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=9875424]

Latest revision as of 14:34, 4 August 2016

Description

Synthetic retinoid. Retinoic acid receptor β (RARβ) agonist in vivo; RARα and RARγ antagonist in vitro. Inhibits breast cell proliferation by inducing active transforming growth factor β (TGFβ) and causes G1 arrest.

Bms 453 structure, image from NCBI Pubchem

Alternative Name

BMS 189453

Chemical Name

4-[(1E)-2-(5,6-Dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl)ethenyl]-benzoic acid

Suppliers

Tocris

References