Vismodegib: Difference between revisions
Jump to navigation
Jump to search
imported>Xenbase Created page with "= Vismodegib= Supplier: MedChem Express; catalog # HY-10440 function: Shh (sonic hedgehog) signal pathway antagonist. Vismodegib treatment to tapdpoles alters the development..." |
imported>Xenbase |
||
| (5 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
Supplier: MedChem Express; catalog # HY-10440 "Vismodegib is an orally active hedgehog pathway inhibitor with an IC50 of 3 nM and also inhibits P-gp, ABCG2 with IC50 values of 3.0 μM and 1.4 μM, respectively." | |||
Supplier: MedChem Express; catalog # HY-10440 | |||
Function: Shh (sonic hedgehog) signal pathway inhibitor. | |||
Phenotypic Effect: Vismodegib treatment of tapdpoles alters the development of the ear, hypaxial muscle, and indirectly, the Mauthner cells, through its interaction with the inner ear afferents. (ref PMID: 29030893) | |||
PubChem CID: 24776445 | |||
Molecular Formula: C19H14Cl2N2O3S | |||
Molecular Weight: 421.292 g/mol | |||
InChI Key: BPQMGSKTAYIVFO-UHFFFAOYSA-N | |||
Synonyms: 879085-55-9; GDC-0449; Erivedge; 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide | |||
Latest revision as of 14:15, 20 January 2021
Supplier: MedChem Express; catalog # HY-10440 "Vismodegib is an orally active hedgehog pathway inhibitor with an IC50 of 3 nM and also inhibits P-gp, ABCG2 with IC50 values of 3.0 μM and 1.4 μM, respectively."
Function: Shh (sonic hedgehog) signal pathway inhibitor.
Phenotypic Effect: Vismodegib treatment of tapdpoles alters the development of the ear, hypaxial muscle, and indirectly, the Mauthner cells, through its interaction with the inner ear afferents. (ref PMID: 29030893)
PubChem CID: 24776445
Molecular Formula: C19H14Cl2N2O3S
Molecular Weight: 421.292 g/mol
InChI Key: BPQMGSKTAYIVFO-UHFFFAOYSA-N
Synonyms: 879085-55-9; GDC-0449; Erivedge; 2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide