XB-FEAT-5957215: Difference between revisions
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= '' | = ''opn4b'' = | ||
This is the community wiki page for the gene '' | This is the community wiki page for the gene ''opn4b'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase. | ||
=synteny= | =synteny= | ||
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''Xtr'' chr1: ''bmpr1b< pdlim5< '''opn4xb'''< hpgds> smarcad1> atoh1< grid2<'' | ''Xtr'' chr1: ''bmpr1b< pdlim5< '''opn4xb'''< hpgds> smarcad1> atoh1< grid2<'' | ||
< | |||
Danio rero (zebrafish) chr5: ''bmpr1ba< LOC110439802, LOC110439803, pdlim5a< '''opn4xb'''< egflam, gdnfb, nipbla, slc1a3a, lmbrd2a'' | |||
=nomenclature updates= | |||
2024 | |||
based on Synteny conservation, this opsin gene was determined to be the probable ortholog of the Zebrafish ''opn4xb'' gene, and then name was changed from the uninformative ''XB5957215'' to ''opn4xb''. | |||
Feb10, 2026 | |||
Gene symbol was reverted to the simple ''opn4b'', as gene symbols should NOT contain an "X for Xenopus". ''opn4x'' and ''opn4xb'' will be placed as synonyms. | |||
=summary of predicted function= | |||
Source: | |||
"Melanopsin (OPN4) is the most well-characterized opsin involved in circadian physiology in mammals. Interestingly, the opn4 gene is duplicated in some non-mammalian vertebrates (opn4 and opn4b; also referred to as opn4m for mammalian and opn4x for Xenopus) and is expressed in the pineal complex of amphibians, reptiles, and birds [2, 18-20]." | |||
refs: | |||
(2) | |||
G. E. Bertolesi, K. Atkinson-Leadbeater, E. M. Mackey, Y. N. Song, B. Heyne, and S. McFarlane, “The Regulation of Skin Pigmentation in Response to Environmental Light by Pineal Type II Opsins and Skin Melanophore Melatonin Receptors,” Journal of Photochemistry and Photobiology, B: Biology 212 (2020): 112024, https://doi.org/10.1016/j.jphotobiol.2020.112024. | |||
(18) 18E. Frigato, D. Vallone, C. Bertolucci, and N. S. Foulkes, “Isolation and Characterization of Melanopsin and Pinopsin Expression Within Photoreceptive Sites of Reptiles,” Naturwissenschaften 93, no. 8 (2006): 379–385. | |||
(19) R. Borges, W. E. Johnson, S. J. O'Brien, V. Vasconcelos, and A. Antunes, “The Role of Gene Duplication and Unconstrained Selective Pressures in the Melanopsin Gene Family Evolution and Vertebrate Circadian Rhythm Regulation,” PLoS One 7, no. 12 (2012): e52413, https://doi.org/10.1371/journal.pone.0052413. | |||
(20) M. W. Baldwin and M. C. Ko, “Functional Evolution of Vertebrate Sensory Receptors,” Hormones and Behavior 124 (2020): 104771, https://doi.org/10.1016/J.YHBEH.2020.104771. | |||
Latest revision as of 18:24, 9 February 2026
opn4b
This is the community wiki page for the gene opn4b please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.
synteny
09MAR2024
Xtr chr1: bmpr1b< pdlim5< opn4xb< hpgds> smarcad1> atoh1< grid2<
Danio rero (zebrafish) chr5: bmpr1ba< LOC110439802, LOC110439803, pdlim5a< opn4xb< egflam, gdnfb, nipbla, slc1a3a, lmbrd2a
nomenclature updates
2024 based on Synteny conservation, this opsin gene was determined to be the probable ortholog of the Zebrafish opn4xb gene, and then name was changed from the uninformative XB5957215 to opn4xb.
Feb10, 2026
Gene symbol was reverted to the simple opn4b, as gene symbols should NOT contain an "X for Xenopus". opn4x and opn4xb will be placed as synonyms.
summary of predicted function
Source: "Melanopsin (OPN4) is the most well-characterized opsin involved in circadian physiology in mammals. Interestingly, the opn4 gene is duplicated in some non-mammalian vertebrates (opn4 and opn4b; also referred to as opn4m for mammalian and opn4x for Xenopus) and is expressed in the pineal complex of amphibians, reptiles, and birds [2, 18-20]." refs: (2) G. E. Bertolesi, K. Atkinson-Leadbeater, E. M. Mackey, Y. N. Song, B. Heyne, and S. McFarlane, “The Regulation of Skin Pigmentation in Response to Environmental Light by Pineal Type II Opsins and Skin Melanophore Melatonin Receptors,” Journal of Photochemistry and Photobiology, B: Biology 212 (2020): 112024, https://doi.org/10.1016/j.jphotobiol.2020.112024.
(18) 18E. Frigato, D. Vallone, C. Bertolucci, and N. S. Foulkes, “Isolation and Characterization of Melanopsin and Pinopsin Expression Within Photoreceptive Sites of Reptiles,” Naturwissenschaften 93, no. 8 (2006): 379–385.
(19) R. Borges, W. E. Johnson, S. J. O'Brien, V. Vasconcelos, and A. Antunes, “The Role of Gene Duplication and Unconstrained Selective Pressures in the Melanopsin Gene Family Evolution and Vertebrate Circadian Rhythm Regulation,” PLoS One 7, no. 12 (2012): e52413, https://doi.org/10.1371/journal.pone.0052413.
(20) M. W. Baldwin and M. C. Ko, “Functional Evolution of Vertebrate Sensory Receptors,” Hormones and Behavior 124 (2020): 104771, https://doi.org/10.1016/J.YHBEH.2020.104771.