XB-FEAT-5867414: Difference between revisions
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=gnrhr2= | =gnrhr2= | ||
This is the community wiki page for the gene ''gnrhr2'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase | This is the community wiki page for the gene ''gnrhr2'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase | ||
=summary from NCBI for human GNRHR2= | |||
'''In non-hominoid primates and non-mammalian vertebrates, the gonadotropin releasing hormone 2 receptor gene (GnRHR2) encodes a seven-transmembrane G-protein coupled receptor'''. However, in human, the corresponding reading frame contains a premature stop codon, which has been suggested to encode a selenocysteine residue, but there is no solid evidence for selenocysteine incorporation (PMID: 12538601). It appears that the human GnRHR2 transcription occurs but the gene does not likely produce a functional multi-transmembrane protein. A non-transcribed pseudogene of GnRHR2 is located on chromosome 14. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2013]. | |||
=nomenclature changes= | |||
3/4/2022 | |||
removed ‘pseudogene’ from gene name, as only human gene is thought to be non-functional. | |||
Latest revision as of 09:08, 8 March 2022
gnrhr2
This is the community wiki page for the gene gnrhr2 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase
summary from NCBI for human GNRHR2
In non-hominoid primates and non-mammalian vertebrates, the gonadotropin releasing hormone 2 receptor gene (GnRHR2) encodes a seven-transmembrane G-protein coupled receptor. However, in human, the corresponding reading frame contains a premature stop codon, which has been suggested to encode a selenocysteine residue, but there is no solid evidence for selenocysteine incorporation (PMID: 12538601). It appears that the human GnRHR2 transcription occurs but the gene does not likely produce a functional multi-transmembrane protein. A non-transcribed pseudogene of GnRHR2 is located on chromosome 14. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2013].
nomenclature changes
3/4/2022
removed ‘pseudogene’ from gene name, as only human gene is thought to be non-functional.