XB-FEAT-6033289: Difference between revisions
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this gene/symbol was renamed from ''XB6033289 provisional ortholog of transient receptor potential cation channel, subfamily C, member 2-like (loc100133315)'' to ''Xrcc1 N-terminal domain containing 1 (xndc1)'' following mouse nomenclature | this gene/symbol was renamed from ''XB6033289 provisional ortholog of transient receptor potential cation channel, subfamily C, member 2-like (loc100133315)'' to ''Xrcc1 N-terminal domain containing 1 (xndc1)'' following mouse nomenclature, andfollowings recommendations after a review by the NCBIs RefSeq project and HUGO Gene Nomenclature Committee | ||
JIRA reference: HGNC-100 | JIRA reference: HGNC-100. URL: [https://ncbijira.ncbi.nlm.nih.gov/browse/HGNC-100] | ||
URL: [https://ncbijira.ncbi.nlm.nih.gov/browse/HGNC-100] | |||
They wrote "In vertebrates we've overlooked annotating the XNDC1 gene upstream of TRPC2 due to over-extension of the TRPC2 CDS (PMID: 21854574). The over-extension of the TRPC2 CDS arose in part because these two genes are pseudogenized in human while readthrough transcription occurs in mouse. Below are suggested updates needed for the proper annotation of the XNDC1 gene." | They wrote "In vertebrates we've overlooked annotating the XNDC1 gene upstream of TRPC2 due to over-extension of the TRPC2 CDS (PMID: 21854574). The over-extension of the TRPC2 CDS arose in part because these two genes are pseudogenized in human while readthrough transcription occurs in mouse. Below are suggested updates needed for the proper annotation of the XNDC1 gene." | ||
9/17/2021 | |||
Human symbol has changed for genepage ID: 6033289 From xndc1 to XNDC1N | |||
Xenopus symbol with remain unchanged at this time. | |||
Revision as of 10:10, 17 September 2021
xndc1
This is the community wiki page for the gene xndc1 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase
synteny Xenopus vs Human
01.01.2021
the identify of this gene needs further investigation
In X tropicalis v10 genome, the order on Chr2 is: lrif1> <trpc2 <loc100133315 numa1> <il18bp tmem216> <lamtor
trpc2 and loc100133315 models may be non overlapping sequences but of the same allele ( ie together they make full trpc2 sequence)
BLAST alignment of the 2 sequences show no significant similarity so loc100133315 does not represent a duplication of trpc2.
nomenclature changes
08.19.2021
this gene/symbol was renamed from XB6033289 provisional ortholog of transient receptor potential cation channel, subfamily C, member 2-like (loc100133315) to Xrcc1 N-terminal domain containing 1 (xndc1) following mouse nomenclature, andfollowings recommendations after a review by the NCBIs RefSeq project and HUGO Gene Nomenclature Committee
JIRA reference: HGNC-100. URL: [1]
They wrote "In vertebrates we've overlooked annotating the XNDC1 gene upstream of TRPC2 due to over-extension of the TRPC2 CDS (PMID: 21854574). The over-extension of the TRPC2 CDS arose in part because these two genes are pseudogenized in human while readthrough transcription occurs in mouse. Below are suggested updates needed for the proper annotation of the XNDC1 gene."
9/17/2021
Human symbol has changed for genepage ID: 6033289 From xndc1 to XNDC1N
Xenopus symbol with remain unchanged at this time.