XB-FEAT-6050251: Difference between revisions
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= | =''piezo1''= | ||
This is the community wiki page for the gene '' | This is the community wiki page for the gene ''piezo1'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase. | ||
=Summary for human PIEZO1 protein from UniProt= | |||
Function | |||
Pore-forming subunit of a mechanosensitive non-specific cation channel (PubMed:23479567, PubMed:23695678). | |||
Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling (PubMed:20016066). | |||
In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation (PubMed:25119035). | |||
Plays a key role in blood vessel formation and vascular structure in both development and adult physiology (By similarity). | |||
Acts as sensor of phosphatidylserine (PS) flipping at the plasma membrane and governs morphogenesis of muscle cells. In myoblasts, flippase-mediated PS enrichment at the inner leaflet of plasma membrane triggers channel activation and Ca2+ influx followed by Rho GTPases signal transduction, leading to assembly of cortical actomyosin fibers and myotube formation. | |||
Miscellaneous | |||
Piezo comes from the Greek 'piesi' meaning pressure. | |||
Activity regulationi | |||
Down-regulated by phosphatidylserines exposed on the cell surface. | |||
Latest revision as of 09:55, 30 November 2021
piezo1
This is the community wiki page for the gene piezo1 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.
Summary for human PIEZO1 protein from UniProt
Function
Pore-forming subunit of a mechanosensitive non-specific cation channel (PubMed:23479567, PubMed:23695678). Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling (PubMed:20016066).
In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation (PubMed:25119035). Plays a key role in blood vessel formation and vascular structure in both development and adult physiology (By similarity). Acts as sensor of phosphatidylserine (PS) flipping at the plasma membrane and governs morphogenesis of muscle cells. In myoblasts, flippase-mediated PS enrichment at the inner leaflet of plasma membrane triggers channel activation and Ca2+ influx followed by Rho GTPases signal transduction, leading to assembly of cortical actomyosin fibers and myotube formation.
Miscellaneous
Piezo comes from the Greek 'piesi' meaning pressure.
Activity regulationi
Down-regulated by phosphatidylserines exposed on the cell surface.