XB-FEAT-983729

cela1.6

This is the community wiki page for the gene cela1.6 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

nomenclature changes

Note: there are 6 tandemly repeated cela1 genes in Xenopus, cela1.1. cela1.2, cela1.3, cela1.4, cela1.5 and cela1.6, that are orthologues of human CELA1

undated change:

Human name has changed for Entrez Gene: 1990. from loc100135144 to chymotrypsin-like elastase family, member 1

01/12/2016

Human name has changed for Entrez Gene: 1990. From chymotrypsin-like elastase family, member 1 to chymotrypsin like elastase family member 1.

05.13.19

The human name has changed for Entrez Gene: 1990. From chymotrypsin like elastase family member 1 to chymotrypsin like elastase 1

Summary from NCBI for human CELA1

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, pancreatic elastase 1 is not expressed in the pancreas. To date, elastase 1 expression has only been detected in skin keratinocytes. Clinical literature that describes human elastase 1 activity in the pancreas or fecal material is actually referring to chymotrypsin-like elastase family, member 3B. [provided by RefSeq, May 2009]