SP600125

Description

MAPK/JNK inhibitor.

"A novel and selective inhibitor of c-Jun N-terminal kinase (JNK) SP600125 is an anthrapyrazolone inhibitor of JNK that competes with ATP to inhibit the phosphorylation of c-Jun. It prevents the activation of inflammatory genes such as COX-2, IL-2 IFN-γ and TNF-α.8,9 It prevents the activation of JNK after brain ischemia and may be effective in treatment of ischemic stroke.10"

• -Sigma Product Description

SP600125 structure, photo from Sigma-Aldrich

Genes Affected

mapk8 mapk1

Suppliers

• Sigma
• Santa Cruz
• Cell Signaling
• Tocris
• Invitrogen
• Abcam

References

• PubChem
• Cizelsky et al., 2014
• Zhang et al., 2013
• Bayliss et al., 2012
• Suzuki et al., 2007
• Ding et al., 2013
• Cha et al., 2008
• Fuentealba et al., 2007
• Cheng et al., 2012
• Choi et al., 2010
• Dickinson et al., 2009
• Li et al., 2008
• Tonge et al., 2008
• Mortensen et al., 2008
• Paek et al., 2010
• Kalin et al., 2009
• Sapkota et al., 2007
• Zacchigna et al., 2006
• Mohney et al., 2003
• Sugiura et al., 2009
• Maurus et al., 2005
• Kusakabe et al., 3071
• Garriock et al., 2005
• Liao et al., 2006
• Du Pasquier et al., 2011
• Hasegawa et al., 2004
• Goss et al., 2001
• Bein et al., 2004
• Hutchins et al., 2013
• Dush et al., 2013
• Luu et al., 2015
• Martinez et al., 2015

>28 Xenbase articles contain a reference to SP600125 according to textpresso

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