IBMX

Description

Phosphodiesterase inhibitor.

"Biochem/physiol Actions: Non-specific inhibitor of cAMP and cGMP phosphodiesterases. The increase in cAMP level as a result of phosphodiesterase inhibition by IBMX activates PKA leading to decreased proliferation, increased differentiation, and induction of apoptosis. IBMX inhibits phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50: 1.3 μM). Also serves as an adenosine receptor antagonist. Shown to inhibit ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. Induces calcium release from intracellular stores in sensory neurons."

• -Sigma Product Description

IBMX structure, photo from Sigma-Aldrich

Suppliers

• Tocris 2845
• Cayman 13347
• Santa Cruz sc-201188
• Enzo
• Life Technologies PHZ1124
• Abcam ab120840
• Sigma-Aldrich i5879

Usage Notes

1mM

References

• PubChem
• Kim et al., 1999

>452 Xenbase articles contain a reference to IMBX according to textpresso

• Back To Small Molecules Home Page