Suramin: Difference between revisions
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==Description== | ==Description== | ||
synonyms: Germanin; Naganol; Naphuride; Belganyl; Suramine | synonyms: Germanin; Naganol; Naphuride; Belganyl; Suramine | ||
"Suramin is a polysulfonated naphthylurea anticancer agent that inhibits tumor cell proliferation. It inhibits the activity of topoisomerase II by blocking the binding of the enzyme to DNA. It′s antiangiogenic activity may be related to its ability to bind to and inhibit the activity of several growth factors, including FGFa, FGFb, and PGDF. It uncouples G-proteins from receptors. It is an broad spectrum antagonist at P2X and P2Y purinergic receptors. Suramin has well documented antiprotozoal and anthelmintic activity." | "Suramin is a polysulfonated naphthylurea anticancer agent that inhibits tumor cell proliferation. It inhibits the activity of topoisomerase II by blocking the binding of the enzyme to DNA. It′s antiangiogenic activity may be related to its ability to bind to and inhibit the activity of several growth factors, including FGFa, FGFb, and PGDF. It uncouples G-proteins from receptors. It is an broad spectrum antagonist at P2X and P2Y purinergic receptors. Suramin has well documented antiprotozoal and anthelmintic activity." | ||
*-Sigma product description | *-Sigma product description | ||
Latest revision as of 12:44, 2 July 2015
Description
synonyms: Germanin; Naganol; Naphuride; Belganyl; Suramine
"Suramin is a polysulfonated naphthylurea anticancer agent that inhibits tumor cell proliferation. It inhibits the activity of topoisomerase II by blocking the binding of the enzyme to DNA. It′s antiangiogenic activity may be related to its ability to bind to and inhibit the activity of several growth factors, including FGFa, FGFb, and PGDF. It uncouples G-proteins from receptors. It is an broad spectrum antagonist at P2X and P2Y purinergic receptors. Suramin has well documented antiprotozoal and anthelmintic activity."
- -Sigma product description
Genes Affected
Topoisomerase II
Suppliers
- Bayer AG
- Sigma
Usage Notes
150mM in culture
References
>209 Xenbase articles contain a reference to suramin according to textpresso