Cyclosporin A

Description

"Cyclic oligopeptide with immunosuppressant properties. Induces apoptosis in rat thymocytes and in the murine B cell lymphoma cell line, WEH1-231. However, prevents anti-IgM and ionomycin-induced apoptosis in BLB cell lines. The complex of cyclosporin A with cyclophilin inhibits protein phosphatase 2B with nanomolar affinity. Inhibits nitric oxide synthesis induced by interleukin-1α, lipopolysaccharides, and TNF-α. Induces cardiomyocytes from embryonic stem cells."

• -Calbiochem Product Description

Synonym

CsA

Cyclosporin A structure, photo from Pubchem

Genes Affected

• ppp3ca (Calcineurin)

Suppliers

• Calbiochem

References

• Pubchem
• Lautermilch et al., 2000

>161 Xenbase articles contain a reference to Cyclosporin A according to textpresso

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