Vismodegib: Difference between revisions
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= Vismodegib= | = Vismodegib= | ||
Supplier: MedChem Express; catalog # HY-10440 | Supplier: MedChem Express; catalog # HY-10440 "Vismodegib is an orally active hedgehog pathway inhibitor with an IC50 of 3 nM and also inhibits P-gp, ABCG2 with IC50 values of 3.0 μM and 1.4 μM, respectively." | ||
Function: Shh (sonic hedgehog) signal pathway antagonist. Vismodegib treatment | Function: Shh (sonic hedgehog) signal pathway antagonist. | ||
Phenotypic Effect: Vismodegib treatment of tapdpoles alters the development of the ear, hypaxial muscle, and indirectly, the Mauthner cells, through its interaction with the inner ear afferents. (ref PMID: 29030893) | |||
Revision as of 07:47, 29 November 2017
Vismodegib
Supplier: MedChem Express; catalog # HY-10440 "Vismodegib is an orally active hedgehog pathway inhibitor with an IC50 of 3 nM and also inhibits P-gp, ABCG2 with IC50 values of 3.0 μM and 1.4 μM, respectively."
Function: Shh (sonic hedgehog) signal pathway antagonist.
Phenotypic Effect: Vismodegib treatment of tapdpoles alters the development of the ear, hypaxial muscle, and indirectly, the Mauthner cells, through its interaction with the inner ear afferents. (ref PMID: 29030893)