XB-FEAT-22172617: Difference between revisions
imported>Xenbase Created page with "=nomenclature updates= 12.31.2019 This genepage was created after a review by David Webb from the NCBI and Xenbase curators. A synteny analysis of ''ripk3'' genes identif..." |
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This | This gene page was created after a review by David Webb from the NCBI and Xenbase curators. | ||
A synteny analysis of ''ripk3'' genes identified this gene ( Entrez gene ID: 100497374) as the Xenopus tropicalis | A synteny analysis of ''ripk3'' genes identified this gene ( Entrez gene ID: 100497374) as the Xenopus tropicalis orthologue of human RIPK3 as its location and gene order is conserved across taxa. | ||
In humans, frog, lizard and turtles, it is found in this gene order: ''nfatc4''> ''ripk3''> ''adcy4''>. | In humans, frog, lizard and turtles, it is found in this gene order: ''nfatc4''> ''ripk3''> ''adcy4''>. | ||
In ''Xenopus tropicalis'' and ''X. laevis'', ripk3 is on Chromosome 1, and | In ''Xenopus tropicalis'' and ''X. laevis'', ripk3 is on Chromosome 1, and chromosome 1.L respectively. | ||
The 2 other ''ripk3'' genes from earlier genome builds are not the true | The 2 other ''ripk3'' genes from earlier genome builds are not the true orthologues of human RIPK3, and have been renamed as ''like'' genes. | ||
In ''X. tropicalis'', '''ripk3-like gene 1''' is on currently placed on Chr2, and in X. Laevis, '''ripk3-like gene 1.L''' it is on Chromosome 8.L, although this needs more study to determine for sure. | In ''X. tropicalis'', '''ripk3-like gene 1''' is on currently placed on Chr2, and in X. Laevis, '''ripk3-like gene 1.L''' it is on Chromosome 8.L, although this needs more study to determine for sure. | ||
Revision as of 10:54, 13 January 2020
nomenclature updates
12.31.2019
This gene page was created after a review by David Webb from the NCBI and Xenbase curators.
A synteny analysis of ripk3 genes identified this gene ( Entrez gene ID: 100497374) as the Xenopus tropicalis orthologue of human RIPK3 as its location and gene order is conserved across taxa.
In humans, frog, lizard and turtles, it is found in this gene order: nfatc4> ripk3> adcy4>.
In Xenopus tropicalis and X. laevis, ripk3 is on Chromosome 1, and chromosome 1.L respectively.
The 2 other ripk3 genes from earlier genome builds are not the true orthologues of human RIPK3, and have been renamed as like genes.
In X. tropicalis, ripk3-like gene 1 is on currently placed on Chr2, and in X. Laevis, ripk3-like gene 1.L it is on Chromosome 8.L, although this needs more study to determine for sure.
Currently, there is no model for ripk3l.2.S ( watch this space!)
It seems that the ripk3l.1 and ripk3l.2 genes do not occur in other vertebrates except the caecillian (Rhinatrema bivittatum), and may represent an amphibian-specific gene duplication event.