4-methylcyclohexane methanol (MCHM): Difference between revisions
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4-methylcyclohexane methanol (MCHM) is coal cleaning chemical. MCHM acts as a hydrotrope ''in vitro'', changing the solubility and protein structure, and changes intracellular levels of a wide range of ions including calcium (Pupo et al 2019 [[https://link.springer.com/article/10.1007/s12011-019-01850-z]]). The molecular target of MCHM is unknown, but biologically active hydrotropes change the liquid-liquid phase separation of transcription factors and RNA binding proteins see references in Perfetto et al 2021 [[https://www.sciencedirect.com/science/article/pii/S2214750020304510?via%3Dihub#bib0065]]. | 4-methylcyclohexane methanol (MCHM) is coal cleaning chemical. MCHM acts as a hydrotrope ''in vitro'', changing the solubility and protein structure, and changes intracellular levels of a wide range of ions including calcium (Pupo et al 2019 [[https://link.springer.com/article/10.1007/s12011-019-01850-z]]). The molecular target of MCHM is unknown, but biologically active hydrotropes change the liquid-liquid phase separation of transcription factors and RNA binding proteins (see references in Perfetto et al 2021 [[https://www.sciencedirect.com/science/article/pii/S2214750020304510?via%3Dihub#bib0065]].) | ||
Latest revision as of 11:47, 11 January 2021
4-methylcyclohexane methanol (MCHM) is coal cleaning chemical. MCHM acts as a hydrotrope in vitro, changing the solubility and protein structure, and changes intracellular levels of a wide range of ions including calcium (Pupo et al 2019 [[1]]). The molecular target of MCHM is unknown, but biologically active hydrotropes change the liquid-liquid phase separation of transcription factors and RNA binding proteins (see references in Perfetto et al 2021 [[2]].)