XB-FEAT-941063: Difference between revisions
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The gene symbol for XB-GENEPAGE-941063 was changed from ''lrrc19'' to ''lrrc19l'', given shared synteny with human ''LRRC19''. | The gene symbol for XB-GENEPAGE-941063 was changed from ''lrrc19'' to ''lrrc19l'', given shared synteny with human ''LRRC19''. | ||
The true ''LRRC19'' gene sequence in human is located in the intronic region of the ''IFT74'' gene, which is flanked by ''TEK'' and ''CAAP1'' genes. This same synteny pattern is observed in a different gene in ''Xenopus'' on chromosome 1 (X.tropicalis NCBI ID:100491155, XB-GENEPAGE-29080546). | The true ''LRRC19'' gene sequence in human is located in the intronic region of the ''IFT74'' gene, which is flanked by ''TEK'' and ''CAAP1'' genes. | ||
This same synteny pattern is observed in a different gene in ''Xenopus'' on chromosome 1 (X.tropicalis NCBI ID:100491155, XB-GENEPAGE-29080546). Thus this gene (XB-GENEPAGE-941063) - now re-named ''lrrc19l'' ("leucine rich repeat containing 19 like") gene in ''Xenopus''- is instead flanked by the ''tie1'' and ''mpl'' genes on one side and ''tmem125'' and ''cfap57'' genes on the other side; This region was examined in humans, and while a syntenic locus was identified, the gene in that position did not blast or align well with this ''lrrc19l'' gene in ''Xenopus'', suggesting it is not represented in humans. | |||
29OCT2024 | |||
removed the human ORF, C1orf210 as ortholog. | |||
Latest revision as of 08:48, 31 October 2024
lrrc19l
This is the community wiki page for the gene lrrc19l please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase
nomenclature
06/27/2024
The gene symbol for XB-GENEPAGE-941063 was changed from lrrc19 to lrrc19l, given shared synteny with human LRRC19.
The true LRRC19 gene sequence in human is located in the intronic region of the IFT74 gene, which is flanked by TEK and CAAP1 genes.
This same synteny pattern is observed in a different gene in Xenopus on chromosome 1 (X.tropicalis NCBI ID:100491155, XB-GENEPAGE-29080546). Thus this gene (XB-GENEPAGE-941063) - now re-named lrrc19l ("leucine rich repeat containing 19 like") gene in Xenopus- is instead flanked by the tie1 and mpl genes on one side and tmem125 and cfap57 genes on the other side; This region was examined in humans, and while a syntenic locus was identified, the gene in that position did not blast or align well with this lrrc19l gene in Xenopus, suggesting it is not represented in humans.
29OCT2024
removed the human ORF, C1orf210 as ortholog.