XB-FEAT-29098714: Difference between revisions
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Created page with "=''mul1''= =nomenclature changes= 13APR2026 ''Xenopus'' gene name changed from ''LOC116412398, mitochondrial ubiquitin ligase activator of nfkb 1-like'' to ''mul1, mitochondrial E3 ubiquitin protein ligase 1'' following assessemtn by NCBi RefSeq curators. In looking at these loci, it is actually GeneID:116412398 (XB-GENE-29098715) which is the ortholog of human MUL1, not GeneID: 100487584 (XB-GENE-5884886). These two loci are in tail-to-tail configuration. The gen..." |
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This is the community wiki page for the '' Xenopus mul1'' genes. Please feel free to record here relevant information about ''mul1'' genes that is not recorded elsewhere on Xenbase. | |||
=nomenclature changes= | =nomenclature changes= | ||
Revision as of 20:48, 15 April 2026
mul1
This is the community wiki page for the Xenopus mul1 genes. Please feel free to record here relevant information about mul1 genes that is not recorded elsewhere on Xenbase.
nomenclature changes
13APR2026
Xenopus gene name changed from LOC116412398, mitochondrial ubiquitin ligase activator of nfkb 1-like to mul1, mitochondrial E3 ubiquitin protein ligase 1 following assessemtn by NCBi RefSeq curators.
In looking at these loci, it is actually GeneID:116412398 (XB-GENE-29098715) which is the ortholog of human MUL1, not GeneID: 100487584 (XB-GENE-5884886).
These two loci are in tail-to-tail configuration. The genomic sequence of GeneID:116412398 (XB-GENE-29098715) supports a 350 aa protein that shares 60% identity (77% similarity) and aligns well across the entire human 349 aa protein. It is supported by transcripts such as CF783801.1 with strong RNA-seq and intron structure support. It is now being represented by NM_001445355.1, encoding the 350 aa protein.
This is in contrast to GeneID: 100487584 (XB-GENE-5884886), where the genome does not support the protein and has a corrected model XM_. This locus has no transcripts that align to the putative CDS and it is unclear if this locus actually represents a protein coding gene.