XB-FEAT-993074: Difference between revisions
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While reviewing this locus, he found another paralog of selenow (GeneID:101731107) on chromosome 3, which is restricted to fish and frog (PMID:22479358). | While reviewing this locus, he found another paralog of selenow (GeneID:101731107) on chromosome 3, which is restricted to fish and frog (PMID:22479358). | ||
This locus | This 2nd locus needed official nomenclature, and will be known by symbol ''selenow2'' with gene name ''selenoprotein W2'' (see below). | ||
To comply with Gladyshev et al.'s recommendation for naming paralogs with suffixes on the symbols (PMID:27645994, Table 3), he suggested the | To comply with Gladyshev et al.'s recommendation for naming paralogs with suffixes on the symbols (PMID:27645994, Table 3), he suggested the | ||
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[[current]] [[changes to > new symbol new name]] | [[current]] [[changes to > new symbol new name]] | ||
selenow (XB-GENE-993075) | selenow (XB-GENE-993075) changed to > selenow1 selenoprotein W1 | ||
new gene GeneID: | new gene GeneID:101731107 changed to > selenow2 selenoprotein W2 | ||
ACTION BY XENBASE: 09/12/17 | ACTION BY XENBASE: 09/12/17 | ||
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NEW GENE PAGE created : XB-GENEPAGE:22041594 | NEW GENE PAGE created : XB-GENEPAGE:22041594 | ||
7.01.2020 | |||
Note that this comes upin the Entrez gene report every month- do not change the name. The human ortholog to selenow1 is SELENOW, and there is no human ortholog to selenow2. | |||
=NCBI summary= | =NCBI summary= | ||
Summary | Summary | ||
This gene encodes a selenoprotein containing a selenocysteine (Sec) residue, which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is highly expressed in skeletal muscle and brain in mammals. It belongs to the SelWTH family, which possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, suggesting a redox function for this gene. Studies in mouse show that this selenoprotein is involved in muscle growth and differentiation, and in the protection of neurons from oxidative stress during neuronal development. A paralog of this gene is found on chromosome 3 (GeneID:101731107). [provided by RefSeq, Aug 2017] | This gene encodes a selenoprotein containing a selenocysteine (Sec) residue, which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is highly expressed in skeletal muscle and brain in mammals. It belongs to the SelWTH family, which possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, suggesting a redox function for this gene. Studies in mouse show that this selenoprotein is involved in muscle growth and differentiation, and in the protection of neurons from oxidative stress during neuronal development. A paralog of this gene is found on chromosome 3 (GeneID:101731107). [provided by RefSeq, Aug 2017] | ||
Revision as of 14:53, 7 July 2020
selenow1
This is the community wiki page for the gene selenow1 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase
nomenclature changes
11/07/2016
Human symbol has changed for genepage ID: 993074 From sepw1 to SELENOW
Human symbol has changed for Entrez Gene: 6415. From SEPW1 to SELENOW
Human name has changed for Entrez Gene: 6415. From selenoprotein W, 1 to selenoprotein W
Mouse symbol has changed for Entrez Gene: 20364. From Sepw1 to Selenow
09/12/2017
correspondance from Bhanu Rajput, Ph. D. [Staff Scientist Reference Sequence Project NCBI/NLM/NIH] 2.) issue concerning selenow gene.
XB-GENE-993075 was previously associated with Entrez GeneID:100145402, which was withdrawn because it was based on a zebrafish transcript (BC160969.1) that was erroneously annotated as Xenopus tropicalis.
He moved XB-GENE-993075 and the official nomenclature (selenow, selenoprotein W) to GeneID:100485593, which now represents Xt selenow gene.
While reviewing this locus, he found another paralog of selenow (GeneID:101731107) on chromosome 3, which is restricted to fish and frog (PMID:22479358).
This 2nd locus needed official nomenclature, and will be known by symbol selenow2 with gene name selenoprotein W2 (see below).
To comply with Gladyshev et al.'s recommendation for naming paralogs with suffixes on the symbols (PMID:27645994, Table 3), he suggested the following nomenclature for the 2 paralogs:
current [[changes to > new symbol new name]]
selenow (XB-GENE-993075) changed to > selenow1 selenoprotein W1
new gene GeneID:101731107 changed to > selenow2 selenoprotein W2
ACTION BY XENBASE: 09/12/17
CHANGED name from SELENOW to SELENOW1 , as requested Submitted SELENOW2 data and requested a new gene page.
NEW GENE PAGE created : XB-GENEPAGE:22041594
7.01.2020 Note that this comes upin the Entrez gene report every month- do not change the name. The human ortholog to selenow1 is SELENOW, and there is no human ortholog to selenow2.
NCBI summary
Summary This gene encodes a selenoprotein containing a selenocysteine (Sec) residue, which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is highly expressed in skeletal muscle and brain in mammals. It belongs to the SelWTH family, which possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, suggesting a redox function for this gene. Studies in mouse show that this selenoprotein is involved in muscle growth and differentiation, and in the protection of neurons from oxidative stress during neuronal development. A paralog of this gene is found on chromosome 3 (GeneID:101731107). [provided by RefSeq, Aug 2017]