XB-FEAT-977342: Difference between revisions
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=pdhb= | =pdhb= | ||
This is the community wiki page for the gene ''pdhb'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase | This is the community wiki page for the gene ''pdhb'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase. | ||
= nomenclature changes= | |||
08/15/2017 | |||
Human name has changed for Entrez Gene: 5162. From pyruvate dehydrogenase (lipoamide) beta to pyruvate dehydrogenase E1 beta subunit. | |||
=summary from NCBI= | |||
The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and carbon dioxide, and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 beta subunit. Mutations in this gene are associated with pyruvate dehydrogenase E1-beta deficiency. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2012] | |||
Latest revision as of 07:44, 15 August 2017
pdhb
This is the community wiki page for the gene pdhb please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.
nomenclature changes
08/15/2017 Human name has changed for Entrez Gene: 5162. From pyruvate dehydrogenase (lipoamide) beta to pyruvate dehydrogenase E1 beta subunit.
summary from NCBI
The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and carbon dioxide, and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 beta subunit. Mutations in this gene are associated with pyruvate dehydrogenase E1-beta deficiency. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2012]