XB-FEAT-5848002: Difference between revisions
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This is the community wiki page for the gene '' | This is the community wiki page for the gene ''XB5848002'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase. | ||
=synonym= | =synonym= | ||
Revision as of 12:06, 30 November 2020
XB5848002
This is the community wiki page for the gene XB5848002 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.
synonym
loc100494211 referred to as 'Bighead' in this article. XB-ART-55302 Bighead is a Wnt antagonist secreted by the Xenopus Spemann organizer that promotes Lrp6 endocytosis Yi Ding, Gabriele Colozza, Eric A. Sosa, Yuki Moriyama, Samantha Rundle, Lukasz Salwinski, and Edward M. De Robertis PNAS published ahead of print September 12, 2018 https://doi.org/10.1073/pnas.1812117115.
protein function and phenotype notes
Bighead is a secreted protein that inhibits Wnt by causing the endocytosis and degradation in lysosomes of the Wnt coreceptor Lrp6. Its overexpression induces embryos with larger heads, and its knockdown reduces head development through the regulation of Wnt signaling.
source: Bighead is a Wnt antagonist secreted by the Xenopus Spemann organizer that promotes Lrp6 endocytosis Yi Ding, Gabriele Colozza, Eric A. Sosa, Yuki Moriyama, Samantha Rundle, Lukasz Salwinski, and Edward M. De Robertis PNAS published ahead of print September 12, 2018 https://doi.org/10.1073/pnas.1812117115.