XB-FEAT-5866765: Difference between revisions
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XB-GENE-5872749) are paralogous genes on chromosome 1 and 4, respectively. | XB-GENE-5872749) are paralogous genes on chromosome 1 and 4, respectively. | ||
selenop encodes a selenoprotein with mutliple selenocysteine (Sec) residues | selenop (GeneID:100379942, XB-GENE-5866766) encodes a selenoprotein with mutliple selenocysteine (Sec) residues (18), similar to SELENOP orthologs in mammals. | ||
(18), similar to SELENOP orthologs in mammals. | |||
'unnamed' has exon structure similar to selenop gene and encodes a protein with high sequence similarity to proteins referred to as selenoprotein Pb or selenoprotein Pb-like | 'unnamed' (GeneID:448755, | ||
XB-GENE-5872749)has exon structure similar to selenop gene and encodes a protein with high sequence similarity to proteins referred to as selenoprotein Pb or selenoprotein Pb-like | |||
(PMIDs:22479358, 11168591), but it is NOT a selenoprotein. | (PMIDs:22479358, 11168591), but it is NOT a selenoprotein. | ||
Revision as of 05:51, 19 September 2017
selenop
This is the community wiki page for the gene selenop please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase
nomenclature changes
11NOV 2016
Human symbol has changed for genepage ID: 5866765 From sepp1 to SELENOP
12SEPT2017 named changed (XB-GENE-5866766) from selenoprotein P, plasma, 1 to selenoprotein P1
symbol changed (XB-GENE-5866766) from selenop to selenop1
correspondance from NIH
09/12/2017 from Bhanu Rajput, Ph. D., Staff Scientist, Reference Sequence Project, NCBI/NLM/NIH.
3. selenop (GeneID:100379942, XB-GENE-5866766) and 'unnamed' (GeneID:448755, XB-GENE-5872749) are paralogous genes on chromosome 1 and 4, respectively.
selenop (GeneID:100379942, XB-GENE-5866766) encodes a selenoprotein with mutliple selenocysteine (Sec) residues (18), similar to SELENOP orthologs in mammals.
'unnamed' (GeneID:448755, XB-GENE-5872749)has exon structure similar to selenop gene and encodes a protein with high sequence similarity to proteins referred to as selenoprotein Pb or selenoprotein Pb-like (PMIDs:22479358, 11168591), but it is NOT a selenoprotein.
Some selenoprotein Pb proteins contain a single Sec residue (e.g., zebrafish NP_840083.2 and chicken NP_001335698.1), but in frog, Sec is replaced by cysteine.
For this reason, naming this locus is hard because it represents a cysteine-containing homolog of selenoprotein Pb protein family.
To comply with Gladyshev et al.'s recommendation for naming paralogs (PMID:22479358 table 3, SELENOP2 is recommended symbol for synonym SELPb), I would like to suggest the following nomenclature update for selenop and 'unnamed', but am open for the naming of the latter: current symbol name
selenop (XB-GENE-5866766) > selenop1 selenoprotein P1
unnamed (XB-GENE-5872749) > selenop2l selenoprotein P2-like
ACTION BY XENBASE: 09/12/17
Changed;
selenop (XB-GENE-5866766) > selenop1 selenoprotein P1
unnamed (XB-GENE-5872749) > selenop2l selenoprotein P2-like
updated names/symbols as requested, added information to wiki