XB-FEAT-5866765

selenop

This is the community wiki page for the gene selenop please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

nomenclature changes

11NOV 2016

Human symbol has changed for genepage ID: 5866765 From sepp1 to SELENOP

12SEPT2017 named changed (XB-GENE-5866766) from selenoprotein P, plasma, 1 to selenoprotein P1

symbol changed (XB-GENE-5866766) from selenop to selenop1  

correspondance from NIH

09/12/2017 from Bhanu Rajput, Ph. D., Staff Scientist, Reference Sequence Project, NCBI/NLM/NIH.

3.  selenop (GeneID:100379942, XB-GENE-5866766) and 'unnamed' (GeneID:448755, XB-GENE-5872749) are paralogous genes on chromosome 1 and 4, respectively.

selenop (GeneID:100379942, XB-GENE-5866766) encodes a selenoprotein with mutliple selenocysteine (Sec) residues (18), similar to SELENOP orthologs in mammals.

'unnamed' (GeneID:448755, XB-GENE-5872749)has exon structure similar to selenop gene and encodes a protein with high sequence similarity to proteins referred to as selenoprotein Pb or selenoprotein Pb-like (PMIDs:22479358, 11168591), but it is NOT a selenoprotein.

Some selenoprotein Pb proteins contain a single Sec residue (e.g., zebrafish NP_840083.2 and chicken NP_001335698.1), but in frog, Sec is replaced by cysteine.

For this reason, naming this locus is hard because it represents a cysteine-containing homolog of selenoprotein Pb protein family.

To comply with Gladyshev et al.'s recommendation for naming paralogs (PMID:22479358 table 3, SELENOP2 is recommended symbol for synonym SELPb), I would like to suggest the following nomenclature update for selenop and 'unnamed', but am open for the naming of the latter:   current                       symbol        name

selenop (XB-GENE-5866766) >   selenop1      selenoprotein P1 

unnamed (XB-GENE-5872749) >   selenop2l     selenoprotein P2-like

ACTION BY XENBASE: 09/12/17 Changed; selenop (XB-GENE-5866766) >   selenop1      selenoprotein P1

unnamed (XB-GENE-5872749) >   selenop2l     selenoprotein P2-like

updated names/symbols as requested, added information to wiki

summary from NCBI

This gene encodes a selenoprotein that is predominantly expressed in the liver and secreted into the plasma in mammals. This selenoprotein is unique in that it contains multiple selenocysteine (Sec) residues per polypeptide (18 in Xenopus tropicalis), and accounts for most of the selenium in plasma. It has been implicated as an extracellular antioxidant, and in the transport of selenium to extra-hepatic tissues via apolipoprotein E receptor-2 (apoER2). Mice lacking this gene exhibit neurological dysfunction, suggesting its importance in normal brain function. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The mRNA for this selenoprotein contains two SECIS elements. [provided by RefSeq, Feb 2017]