AZD1480: Difference between revisions
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*[http://www.xenbase.org/literature/article.do?method=display&articleId=50713 Hyakutake et al., 2015] | *[http://www.xenbase.org/literature/article.do?method=display&articleId=50713 Hyakutake et al., 2015] | ||
*[http://www.xenbase.org/literature/article.do?method=display&articleId=42239 Bergmann et al., 2010] | *[http://www.xenbase.org/literature/article.do?method=display&articleId=42239 Bergmann et al., 2010] | ||
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*[[Small Molecules for Xenopus Research|Back To Small Molecules Home Page]] | |||
Revision as of 06:55, 1 June 2015
Description
Inhibits the Jak Stat pathway. AZD1480 is a novel ATP-competitive JAK2 inhibitor with IC50 of 0.26 nM in a cell-free assay, selectivity against JAK3 and Tyk2, and to a smaller extent against JAK1. Phase 1.
