ZM 447439: Difference between revisions
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==Description== | ==Description== | ||
"Novel, selective ATP-competitive inhibitor of Aurora B kinase in vitro (IC50 values are 50, 250 and 1000 nM for Aurora B, C and A kinases respectively). Selective over a range of other kinases including cdk1 and PLK1 (IC50 > 10 μM). Inhibits cell division and displays selective toxicity towards proliferating tumor cells versus non-dividing cells." | |||
*-Tocris product description | |||
[[File:ZM447439.png|frame|right|ZM 447439 structure, photo from Pubchem]] | [[File:ZM447439.png|frame|right|ZM 447439 structure, photo from Pubchem]] | ||
Latest revision as of 14:07, 2 July 2015
Description
"Novel, selective ATP-competitive inhibitor of Aurora B kinase in vitro (IC50 values are 50, 250 and 1000 nM for Aurora B, C and A kinases respectively). Selective over a range of other kinases including cdk1 and PLK1 (IC50 > 10 μM). Inhibits cell division and displays selective toxicity towards proliferating tumor cells versus non-dividing cells."
- -Tocris product description
Genes Affected
Suppliers
- EMD Millipore
- Tocris
- Selleck
- Santa Cruz
- Cayman
- Enzo
Usage Notes
20uM
References
>1 Xenbase articles contain a reference to ZM 447439 according to textpresso