XB-FEAT-6071789: Difference between revisions
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This is the community wiki page for the gene ''flt1'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase | This is the community wiki page for the gene ''flt1'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase | ||
=orthology and synteny notes= | =orthology and synteny notes for ''kdrl'' v. ''flt1''= | ||
24APRIL2023 | |||
Despite suggestions from DIOPT Analysis, | Despite suggestions from DIOPT Analysis, ''Xenopus'' ''kdrl'' genes are not orthologous with human ITL1. Note: There does '''not''' appear to be an orthologous mammalian gene for ''kdrl'', and it only annotated in fishes and frogs. (ie it is missing in human and other mammals) | ||
In Xtrop and | In Xtrop and in Zebrafish, ''kdrl'' is adjacent to ''chic1'' and ''cdx4'': | ||
Xtr.chr8: amer1> ... arhgef9> ... '''kdrl>''' ... loc#> ... cdx4> ... chic1> | |||
Xla.chr8L: amer1.L> ... arhgef9.L> ... '''kdrl.L>''' ... cdx4.L> ... | |||
Dre.chr14: gdpd2< ... dlg3< ...tex11> ... '''kdrl>''' ... cdx4> ... chic1> | |||
Whereas ''flt1'' is flanked by ''slc46a3'' and ''pan3'' in all mammals, fish and frogs | |||
Xtr.chr: slc46a3 ...'''flt1''' ... pan3 ... | |||
Xla.chrL: slc46a3.L ... '''flt1.L''' ... pan3 .. flt3 | |||
Human CHR13: SLC46A3 ... '''FLT1'''...PAN3 ...FLT3 | |||
Dre.chr: slc46a3 ... '''flt1''' ... pan3 .. flt3 | |||
=synteny of ''flt1'' versus ''kdr1''= | =synteny of ''flt1'' versus ''kdr1''= | ||
Revision as of 08:53, 25 April 2023
flt1
This is the community wiki page for the gene flt1 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase
orthology and synteny notes for kdrl v. flt1
24APRIL2023
Despite suggestions from DIOPT Analysis, Xenopus kdrl genes are not orthologous with human ITL1. Note: There does not appear to be an orthologous mammalian gene for kdrl, and it only annotated in fishes and frogs. (ie it is missing in human and other mammals)
In Xtrop and in Zebrafish, kdrl is adjacent to chic1 and cdx4:
Xtr.chr8: amer1> ... arhgef9> ... kdrl> ... loc#> ... cdx4> ... chic1>
Xla.chr8L: amer1.L> ... arhgef9.L> ... kdrl.L> ... cdx4.L> ...
Dre.chr14: gdpd2< ... dlg3< ...tex11> ... kdrl> ... cdx4> ... chic1>
Whereas flt1 is flanked by slc46a3 and pan3 in all mammals, fish and frogs
Xtr.chr: slc46a3 ...flt1 ... pan3 ...
Xla.chrL: slc46a3.L ... flt1.L ... pan3 .. flt3
Human CHR13: SLC46A3 ... FLT1...PAN3 ...FLT3
Dre.chr: slc46a3 ... flt1 ... pan3 .. flt3
synteny of flt1 versus kdr1
Synteny across Xenopus is highly conserved for flt1:
Xtrop: mtus2 > [LOC#9015(p) LOC#9139(unch) LOC(unch) LOC#9957] flt1> pan3< flt3>
Xla.L : mtus2.L > slc46a3.L flt1.L> pan3.L< flt3.L>
Xla.S : mtus2.S > slc46a3.S flt1.S> pan3.S< flt3.S>